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EJNMMI Research
Figure 1 | EJNMMI Research

Figure 1

From: In vivo PET imaging of beta-amyloid deposition in mouse models of Alzheimer's disease with a high specific activity PET imaging agent [18F]flutemetamol

Figure 1

In vivo [18F ]flutemetamol retention in the brain of mouse models of AD. Sagittal PET/CT images summed over 40 to 60 min after [18F]flutemetamol injection are shown for (a) APP23, (b) Tg2576 and (c) APPswe-PS1dE9 mice. Increased [18F]flutemetamol retention (yellow) was detected in the cerebral cortex of aged APP23 mice (18 and 21 months), but signals in aged Tg2576 (19 and 22 months) and APPswe-PS1dE9 (19 months) mice were similar to those of the young (9 months) transgenic mice. White arrows, frontal cortex; red arrows, cerebellum; mo, age of animal in months.

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