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EJNMMI Research
Figure 6 | EJNMMI Research

Figure 6

From: Evaluation of efficacy of a new MEK inhibitor, RO4987655, in human tumor xenografts by [18F] FDG-PET imaging combined with proteomic approaches

Figure 6

Ingenuity pathway analysis of the RO4987655 treatment effects on regulation of MAPK/PI3K/AKT pathway phospho-proteins. (a) Day 1 and (b) day 3 of the treatment (colored markers for scores measured on the RPPA platform, green - negative and red - positive dose-related regulation). The first column in the bar chat represents the regulation of the total protein, the second column the regulation of the corresponding phospho-protein. In cases where more than one phospho sites were measured for the same protein, the third (and so forth) column represents the regulation for the second (and so forth) phospho-protein. The grey nodes represent proteins where only the total proteins were measured but no phosphorylated forms.

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