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Table 3 Lung quantification results

From: Personalized predictive lung dosimetry by technetium-99m macroaggregated albumin SPECT/CT for yttrium-90 radioembolization

Item

Mean ± SD; median; 95%CI; range

ttest

Bias ± SD; 95%LOA

Lung mean density (g/cm3)

   

 Diagnostic CT

   

  Right lung

0.215 ± 0.049; 0.201; 0.197 to 0.232; 0.121 to 0.376

  

  Left lung, compared to right

0.217 ± 0.054; 0.201; 0.197 to 0.236; 0.128 to 0.383

p = 0.44

+0.0019 ± 0.0131; −0.0239 to +0.0276

  Mean of both lungs

0.216 ± 0.051; 0.206; 0.197 to 0.234; 0.125 to 0.379

  

 SPECT/CT

   

  Right lung

0.291 ± 0.051; 0.289; 0.273 to 0.309; 0.180 to 0.410

  

  Left lung, compared to right

0.306 ± 0.064; 0.310; 0.273 to 0.309; 0.161 to 0.442

p = 0.002

+0.0152 ± 0.0243; −0.0324 to +0.0628

  Mean of both lungs, compared to diagnostic CT

0.299 ± 0.056; 0.298; 0.278 to 0.319; 0.171 to 0.417

p <0.001

 

Lung parenchyma mass (g)

   

 Diagnostic CT

   

  All patients

822 ± 103; 809; 785 to 859; 621 to 1,107

  

   Male

828 ± 114; 823; 783 to 874; 621 to 1,107

  

   Female

795 ± 19; 801; 780 to 811; 764 to 812

  

 SPECT/CT

   

  All patients, compared to diagnostic CT

788 ± 110; 736; 748 to 827; 624 to 1,045

p = 0.19

−21.7 ± 88.2; −194.6 to +151.2

Lung volume (cm3)

   

 Diagnostic CT

3,967 ± 798; 4,049; 3,682 to 4,253; 2,142 to 5,634

  

 SPECT/CT, compared to diagnostic CT

2,749 ± 744; 2,530; 483 to 3,015; 1,698 to 5,199

p <0.001

 

Lung shunt fraction (%)

   

 SPECT/CT

5.96 ± 4.59; 4.97; 4.32 to 7.61; 0.98 to 21.71

  

 Planar, compared to SPECT/CT

7.36 ± 4.96; 6.03; 5.58 to 9.14; 2.20 to 25.26

p <0.001

+1.40 ± 1.60; −1.73 to +4.52

Lung Dmean (Gy)

   

 Reference Dmean

6.16 ± 5.24; 3.64; 4.28 to 8.03; 0.76 to 17.52

  

  Planar, compared to reference

6.07 ± 4.51; 4.75; 4.46 to 7.68; 1.00 to 16.02

p = 0.78

−0.09 ± 1.73; −3.48 to +3.31

  SPECT/CT, compared to reference

6.48 ± 5.51; 4.06; 4.51 to 8.45; 0.85 to 18.87

p = 0.11

+0.32 ± 1.06; −1.76 to +2.40

  Planar, compared to SPECT/CT

 

p = 0.27

−0.41 ± 2.00; −4.32 to +3.50