Biodistribution (%iA/g) | ||||
---|---|---|---|---|
0.5 h | 1 h | 2 h | 2 h blocked | |
Ex4NOD12 | ||||
Blood | 0.84 ± 0.11 | 0.32 ± 0.16 | 0.18 ± 0.01 | 0.19 ± 0.04 |
Heart | 0.78 ± 0.13 | 0.44 ± 0.07 | 0.51 ± 0.35 | 0.26 ± 0.06 |
Lung | 18.59 ± 2.62 | 22.67 ± 5.36 | 25.47 ± 2.02 | 0.37 ± 0.08 |
Spleen | 1.06 ± 0.11 | 1.06 ± 0.56 | 0.44 ± 0.05 | 0.75 ± 0.31 |
Kidneys | 142.52 ± 24.51 | 133.35 ± 22.18 | 104.20 ± 12.02 | 136.72 ± 9.41 |
Pancreas | 5.57 ± 0.53 | 6.93 ± 2.64 | 4.52 ± 0.96 | 1.23 ± 0.91 |
Stomach | 1.59 ± 0.78 | 0.77 ± 0.24 | 0.75 ± 0.49 | 0.20 ± 0.07 |
Intestines | 0.83 ± 0.23 | 0.52 ± 0.05 | 0.74 ± 0.10 | 0.13 ± 0.02 |
Liver | 1.09 ± 0.19 | 0.91 ± 0.19 | 0.31 ± 0.05 | 1.88 ± 0.23 |
Muscle | 0.43 ± 0.11 | 0.21 ± 0.03 | 0.19 ± 0.07 | 0.26 ± 0.16 |
Bone | 0.98 ± 0.90 | 0.42 ± 0.16 | 0.23 ± 0.02 | 0.36 ± 0.10 |
Tumour | 9.44 ± 3.94 | 8.92 ± 1.08 | 8.29 ± 1.50 | 0.83 ± 0.17 |
Ex4NOD27 | ||||
Blood | 0.88 ± 0.09 | 0.36 ± 0.09 | 0.24 ± 0.04 | 0.23 ± 0.05 |
Heart | 0.62 ± 0.05 | 0.44 ± 0.02 | 0.41 ± 0.04 | 0.27 ± 0.02 |
Lung | 16.56 ± 2.74 | 13.79 ± 2.04 | 11.63 ± 4.51 | 0.43 ± 0.18 |
Spleen | 0.81 ± 0.08 | 2.72 ± 0.55 | 0.89 ± 0.40 | 0.58 ± 0.30 |
Kidneys | 117.21 ± 5.47 | 124.50 ± 12.13 | 143.00 ± 34.71 | 122.30 ± 35.13 |
Pancreas | 4.10 ± 0.54 | 4.91 ± 1.61 | 6.89 ± 1.81 | 0.87 ± 0.10 |
Stomach | 0.93 ± 0.16 | 0.92 ± 0.27 | 0.79 ± 0.39 | 0.19 ± 0.13 |
Intestines | 0.40 ± 0.07 | 0.66 ± 0.19 | 0.71 ± 0.40 | 0.24 ± 0.11 |
Liver | 1.36 ± 0.10 | 6.31 ± 0.27 | 1.04 ± 0.17 | 0.65 ± 0.22 |
Muscle | 0.33 ± 0.04 | 0.38 ± 0.09 | 0.29 ± 0.05 | 0.18 ± 0.10 |
Bone | 0.56 ± 0.16 | 0.89 ± 0.22 | 0.47 ± 0.08 | 0.29 ± 0.11 |
Tumour | 7.26 ± 2.32 | 5.18 ± 0.98 | 4.69 ± 0.98 | 0.97 ± 0.07 |
Ex4NOD40 | ||||
Blood | 1.15 ± 0.37 | 0.72 ± 0.33 | 0.66 ± 0.17 | 0.48 ± 0.10 |
Heart | 0.94 ± 0.34 | 0.56 ± 0.24 | 0.57 ± 0.08 | 0.41 ± 0.12 |
Lung | 22.83 ± 8.04 | 26.28 ± 6.46 | 25.67 ± 7.94 | 0.77 ± 0.12 |
Spleen | 1.73 ± 0.51 | 1.23 ± 0.37 | 1.60 ± 0.43 | 1.50 ± 0.38 |
Kidneys | 101.14 ± 22.60 | 110.35 ± 24.27 | 127.51 ± 11.58 | 168.66 ± 48.22 |
Pancreas | 5.05 ± 1.02 | 6.73 ± 1.65 | 6.80 ± 1.80 | 2.63 ± 1.34 |
Stomach | 1.80 ± 0.48 | 0.82 ± 0.28 | 1.78 ± 0.67 | 0.34 ± 0.12 |
Intestines | 1.01 ± 0.34 | 0.72 ± 0.17 | 1.19 ± 0.37 | 0.31 ± 0.03 |
Liver | 2.71 ± 0.71 | 2.28 ± 0.44 | 2.47 ± 0.77 | 2.75 ± 1.13 |
Muscle | 0.46 ± 0.20 | 0.34 ± 0.16 | 0.44 ± 0.17 | 0.33 ± 0.14 |
Bone | 0.66 ± 0.16 | 0.58 ± 0.22 | 1.24 ± 0.67 | 0.75 ± 0.35 |
Tumour | 7.30 ± 0.94 | 6.60 ± 0.35 | 9.04 ± 1.97 | 2.39 ± 0.87 |