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Table 1 Biodistribution of the 68 Ga-labelled peptides in CD1 nu/nu mice

From: A comparison of three 67/68Ga-labelled exendin-4 derivatives for β-cell imaging on the GLP-1 receptor: the influence of the conjugation site of NODAGA as chelator

 

Biodistribution (%iA/g)

 

0.5 h

1 h

2 h

2 h blocked

Ex4NOD12

 

Blood

0.84 ± 0.11

0.32 ± 0.16

0.18 ± 0.01

0.19 ± 0.04

Heart

0.78 ± 0.13

0.44 ± 0.07

0.51 ± 0.35

0.26 ± 0.06

Lung

18.59 ± 2.62

22.67 ± 5.36

25.47 ± 2.02

0.37 ± 0.08

Spleen

1.06 ± 0.11

1.06 ± 0.56

0.44 ± 0.05

0.75 ± 0.31

Kidneys

142.52 ± 24.51

133.35 ± 22.18

104.20 ± 12.02

136.72 ± 9.41

Pancreas

5.57 ± 0.53

6.93 ± 2.64

4.52 ± 0.96

1.23 ± 0.91

Stomach

1.59 ± 0.78

0.77 ± 0.24

0.75 ± 0.49

0.20 ± 0.07

Intestines

0.83 ± 0.23

0.52 ± 0.05

0.74 ± 0.10

0.13 ± 0.02

Liver

1.09 ± 0.19

0.91 ± 0.19

0.31 ± 0.05

1.88 ± 0.23

Muscle

0.43 ± 0.11

0.21 ± 0.03

0.19 ± 0.07

0.26 ± 0.16

Bone

0.98 ± 0.90

0.42 ± 0.16

0.23 ± 0.02

0.36 ± 0.10

Tumour

9.44 ± 3.94

8.92 ± 1.08

8.29 ± 1.50

0.83 ± 0.17

Ex4NOD27

 

Blood

0.88 ± 0.09

0.36 ± 0.09

0.24 ± 0.04

0.23 ± 0.05

Heart

0.62 ± 0.05

0.44 ± 0.02

0.41 ± 0.04

0.27 ± 0.02

Lung

16.56 ± 2.74

13.79 ± 2.04

11.63 ± 4.51

0.43 ± 0.18

Spleen

0.81 ± 0.08

2.72 ± 0.55

0.89 ± 0.40

0.58 ± 0.30

Kidneys

117.21 ± 5.47

124.50 ± 12.13

143.00 ± 34.71

122.30 ± 35.13

Pancreas

4.10 ± 0.54

4.91 ± 1.61

6.89 ± 1.81

0.87 ± 0.10

Stomach

0.93 ± 0.16

0.92 ± 0.27

0.79 ± 0.39

0.19 ± 0.13

Intestines

0.40 ± 0.07

0.66 ± 0.19

0.71 ± 0.40

0.24 ± 0.11

Liver

1.36 ± 0.10

6.31 ± 0.27

1.04 ± 0.17

0.65 ± 0.22

Muscle

0.33 ± 0.04

0.38 ± 0.09

0.29 ± 0.05

0.18 ± 0.10

Bone

0.56 ± 0.16

0.89 ± 0.22

0.47 ± 0.08

0.29 ± 0.11

Tumour

7.26 ± 2.32

5.18 ± 0.98

4.69 ± 0.98

0.97 ± 0.07

Ex4NOD40

 

Blood

1.15 ± 0.37

0.72 ± 0.33

0.66 ± 0.17

0.48 ± 0.10

Heart

0.94 ± 0.34

0.56 ± 0.24

0.57 ± 0.08

0.41 ± 0.12

Lung

22.83 ± 8.04

26.28 ± 6.46

25.67 ± 7.94

0.77 ± 0.12

Spleen

1.73 ± 0.51

1.23 ± 0.37

1.60 ± 0.43

1.50 ± 0.38

Kidneys

101.14 ± 22.60

110.35 ± 24.27

127.51 ± 11.58

168.66 ± 48.22

Pancreas

5.05 ± 1.02

6.73 ± 1.65

6.80 ± 1.80

2.63 ± 1.34

Stomach

1.80 ± 0.48

0.82 ± 0.28

1.78 ± 0.67

0.34 ± 0.12

Intestines

1.01 ± 0.34

0.72 ± 0.17

1.19 ± 0.37

0.31 ± 0.03

Liver

2.71 ± 0.71

2.28 ± 0.44

2.47 ± 0.77

2.75 ± 1.13

Muscle

0.46 ± 0.20

0.34 ± 0.16

0.44 ± 0.17

0.33 ± 0.14

Bone

0.66 ± 0.16

0.58 ± 0.22

1.24 ± 0.67

0.75 ± 0.35

Tumour

7.30 ± 0.94

6.60 ± 0.35

9.04 ± 1.97

2.39 ± 0.87