Figure 6
From: Imaging RAGE expression in atherosclerotic plaques in hyperlipidemic pigs
Hind limb imaging and histology. Top 4 images are coronal (left) and sagittal (right) slices from SPECT/CT scans of hind limbs of farm pig (above) and HL pig (below) injected with 99mTc anti-RAGE F(ab′)2. There is diffuse tracer uptake in both hind limbs of the HL pig compared to low uptake in the farm pig. Bottom images on the left are the CTA showing atheroma at the iliac bifurcation in a HL pig and on the right the H&E-stained cross-sections from the femoral artery of a HL pig showing fibrous atheroma and from the gastrocnemius muscle of a HL pig showing RAGE staining in the small arterial walls.