Evaluation of [11C]oseltamivir uptake into the brain during immune activation by systemic polyinosine-polycytidylic acid injection: a quantitative PET study using juvenile monkey models of viral infection

EJNMMI Research

Table 1 Unlabeled drug concentrations in plasma

Animal	Dose (mg/kg)		Plasma concentration at 1 min (ng/mL)				AUC (1 to 60 min) (ng/mL × min)
			Oseltamivir		Ro 64-0802		Oseltamivir		Ro 64-0802
	Baseline	Poly I:C	Baseline	Poly I:C	Baseline	Poly I:C	Baseline	Poly I:C	Baseline	Poly I:C
M176	3.4	3.3	590	281	622	494	14,437	10,237	43,252	38,523
F175	3.0	3.0	282	222	749	727	9,291	7,782	48,849	45,976
F174	3.2	3.3	343	190	1,004	1,093	10,667	5,238	65,966	48,924
Mean	3.2	3.2	405	231	792	772	11,465	7,752	52,689	44,474
SD	0.2	0.1	163	46	195	302	2,664	2,500	11,834	5,361