Skip to main content

Table 3 Analysis of tumour cell density, vascularity, and antibody penetrance

From: Quantitative intratumoural microdistribution and kinetics of 131I-huA33 antibody in patients with colorectal carcinoma

TUMOUR CELL DENSITY
Patient no. Mean number of viable tumour cells/field of viable peripheral tumour areasa Mean number of viable tumour cells/field of necrotic central tumour areasa p-valueb
3 388±185 32±33  
4 408±170 80±33  
5 249±128 28±33  
6 243±34 54±17  
12 274±127 79±62  
Mean±SD 313±146 54±42 P<0.001
MICROVESSEL DENSITY(MVD)
Patient no. Mean number of vessels/mm 2 in peripheral tumour areas Mean number of vessels/mm 2 in central tumour areas p-value b
3 54±23 21±16  
4 52±12 13±6.4  
5 64±27 20±9  
6 39±6 17±15  
12 52±23 23±8  
Mean±SD 52±20 19±11 P<0.001
ANTIBODY PENETRATION DISTANCE
Patient no. Mean distance cell-vessel (μm) in peripheral tumour areas (range) Mean distance cell-vessel (μm) in central tumour areas (range) p-value b
3 5.5±3 (2.5-10.5) 48.7 ±23.8 (23.8-79.4)  
4 6.7±2.2 (3.9-10) 82.5±29.3 (45.1-118)  
5 14.7±7.8 (3.3-25.2) 53.9±17.4 (33.6-80)  
6 13.7±4.2 (9-18.4) 46.8±8.2 (39.1-59)  
12 11.7±9 (1.7-26) 41.1±14.2 (20.3-57.2)  
Mean±SD 10.5±6.6 54.6±23.5 P<0.001
INTERCAPILLARY DISTANCE (ICD)
Patient no. Mean ICD (μm) in peripheral tumour areas Mean ICD (μm) in central tumour areas p-value b
3 52.6±22.1 205.6±11.1  
4 63.2±33.5 410.2±135.5  
5 43.3±15.5 91.7±25.1  
6 103.4±37.8 185±58.4  
12 82.9±33.6 195.1±112.2  
Mean±SD 69.4±34.5 207.4±121.7 P<0.001
  1. aField area = 0.118 mm2.
  2. bP-value comparing central versus peripheral tumour areas using Mann-Whitney U Test.