Quantitative intratumoural microdistribution and kinetics of 131I-huA33 antibody in patients with colorectal carcinoma

EJNMMI Research

Table 3 Analysis of tumour cell density, vascularity, and antibody penetrance

TUMOUR CELL DENSITY
Patient no.	Mean number of viable tumour cells/field of viable peripheral tumour areas^a	Mean number of viable tumour cells/field of necrotic central tumour areas^a	p-value^b
3	388±185	32±33
4	408±170	80±33
5	249±128	28±33
6	243±34	54±17
12	274±127	79±62
Mean±SD	313±146	54±42	P<0.001
MICROVESSEL DENSITY(MVD)
Patient no.	Mean number of vessels/mm ² in peripheral tumour areas	Mean number of vessels/mm ² in central tumour areas	p-value ^b
3	54±23	21±16
4	52±12	13±6.4
5	64±27	20±9
6	39±6	17±15
12	52±23	23±8
Mean±SD	52±20	19±11	P<0.001
ANTIBODY PENETRATION DISTANCE
Patient no.	Mean distance cell-vessel (μm) in peripheral tumour areas (range)	Mean distance cell-vessel (μm) in central tumour areas (range)	p-value ^b
3	5.5±3 (2.5-10.5)	48.7 ±23.8 (23.8-79.4)
4	6.7±2.2 (3.9-10)	82.5±29.3 (45.1-118)
5	14.7±7.8 (3.3-25.2)	53.9±17.4 (33.6-80)
6	13.7±4.2 (9-18.4)	46.8±8.2 (39.1-59)
12	11.7±9 (1.7-26)	41.1±14.2 (20.3-57.2)
Mean±SD	10.5±6.6	54.6±23.5	P<0.001
INTERCAPILLARY DISTANCE (ICD)
Patient no.	Mean ICD (μm) in peripheral tumour areas	Mean ICD (μm) in central tumour areas	p-value ^b
3	52.6±22.1	205.6±11.1
4	63.2±33.5	410.2±135.5
5	43.3±15.5	91.7±25.1
6	103.4±37.8	185±58.4
12	82.9±33.6	195.1±112.2
Mean±SD	69.4±34.5	207.4±121.7	P<0.001

^aField area = 0.118 mm².
^bP-value comparing central versus peripheral tumour areas using Mann-Whitney U Test.