Skip to main content

Table 2 Percent injected 131 I-huA33 dose per gram of tumour measured by gamma well counter and autoradiography

From: Quantitative intratumoural microdistribution and kinetics of 131I-huA33 antibody in patients with colorectal carcinoma

Patient no. Range of tumour uptake %ID/g × 10−3(gamma well counter) Whole tumour %ID/g × 10−3(autoradiography) Tumour centre %ID/g × 10−3(autoradiography) Tumour periphery %ID/g × 10−3(autoradiography) pvalued
1 NEa NEa NEa NEa  
2 NEa NEa NEa NEa  
3 2.7-5.3 NEc 0.556 (N) 0.683  
4 5.3-14.1 3.09 0.947 (N) 3.24  
5 3.2-7.6 0.837 0.180 (N) 1.02  
6 1.7-5.0 NEc 1.25 (N) 4.06  
7ab 5.2-6.5 5.77 NEc NEc  
7bb NEc 6.22 NEc NEc  
7cb 5.2-6.5 6.37 NEc NEc  
8 1.4-4.5 NEc 4.27 (V) 3.53  
9 3.2-5.5 NEc 3.97 (V) 7.25  
10 0.6-5.1 NEc NEc 7.20  
11 9.5-12.4 8.43 NEc NEc  
12 3.6-8.1 NEc 0.0970 (N) 5.90  
Mean ± SD (N)    0.606 ± 0.493 2.98 ± 2.17 0.06
Mean ± SD (V)    4.12 ± 0.212 5.39 ± 2.63 NAe
Mean ± SD (all) 5.13 ± 1.76 5.12 ± 2.71 1.61 ± 1.76 4.11 ± 2.53 0.07
  1. aData from patients 1 and 2 were not available due to technical problems; bpatient 7 had three primary colonic tumours resected and were analyzed separately; cthe tumours from patients 3, 6, 8, 9, 10, and 12 were too large for whole tumour autoradiographs to be constructed; tumours from patient 7 and 11 were too small to determine central and peripheral areas; there was no tissue from patient 10 labelled as ‘tumour centre’; dp value comparing 131I-huA33 uptake in tumour centres and tumour peripheries using Mann-Whitney U test; ep value not available due to limited patient numbers. %ID/g, percent injected dose per gram; N, necrotic areas; V, viable areas; NE, not evaluable; SD, standard deviation; NA, not applicable.