Quantitative intratumoural microdistribution and kinetics of 131I-huA33 antibody in patients with colorectal carcinoma

EJNMMI Research

Table 2 Percent injected ¹³¹ I-huA33 dose per gram of tumour measured by gamma well counter and autoradiography

Patient no.	Range of tumour uptake %ID/g × 10⁻³(gamma well counter)	Whole tumour %ID/g × 10⁻³(autoradiography)	Tumour centre %ID/g × 10⁻³(autoradiography)	Tumour periphery %ID/g × 10⁻³(autoradiography)	pvalue^d
1	NE^a	NE^a	NE^a	NE^a
2	NE^a	NE^a	NE^a	NE^a
3	2.7-5.3	NE^c	0.556 (N)	0.683
4	5.3-14.1	3.09	0.947 (N)	3.24
5	3.2-7.6	0.837	0.180 (N)	1.02
6	1.7-5.0	NE^c	1.25 (N)	4.06
7a^b	5.2-6.5	5.77	NE^c	NE^c
7b^b	NE^c	6.22	NE^c	NE^c
7c^b	5.2-6.5	6.37	NE^c	NE^c
8	1.4-4.5	NE^c	4.27 (V)	3.53
9	3.2-5.5	NE^c	3.97 (V)	7.25
10	0.6-5.1	NE^c	NE^c	7.20
11	9.5-12.4	8.43	NE^c	NE^c
12	3.6-8.1	NE^c	0.0970 (N)	5.90
Mean ± SD (N)			0.606 ± 0.493	2.98 ± 2.17	0.06
Mean ± SD (V)			4.12 ± 0.212	5.39 ± 2.63	NA^e
Mean ± SD (all)	5.13 ± 1.76	5.12 ± 2.71	1.61 ± 1.76	4.11 ± 2.53	0.07

^aData from patients 1 and 2 were not available due to technical problems; ^bpatient 7 had three primary colonic tumours resected and were analyzed separately; ^cthe tumours from patients 3, 6, 8, 9, 10, and 12 were too large for whole tumour autoradiographs to be constructed; tumours from patient 7 and 11 were too small to determine central and peripheral areas; there was no tissue from patient 10 labelled as ‘tumour centre’; ^dp value comparing 131I-huA33 uptake in tumour centres and tumour peripheries using Mann-Whitney U test; ^ep value not available due to limited patient numbers. %ID/g, percent injected dose per gram; N, necrotic areas; V, viable areas; NE, not evaluable; SD, standard deviation; NA, not applicable.