Figure 2From: Peptide receptor radionuclide therapy (PRRT) with [177Lu-DOTA0,Tyr3]octreotate in combination with RAD001 treatment: further investigations on tumor metastasis and response in the rat pancreatic CA20948 tumor modelGraphs showing percentage of rats having primary tumors and metastases, and mean body weight of animals. (A) Percentage of (LEW/SsNHsd Lewis) rats with primary tumors reaching the maximum size of >6Â cm3 that underwent surgery afterwards to remove the tumor. The control group received saline. RAD001 therapy started at day 4 (5Â mg/kg administered twice weekly). 177Lu-DOTATATE (125Â MBq) was administered at day 1. (B) Percentage of (LEW/SsNHsd Lewis) rats developing metastases in each group. (C) Mean body weight of animals in the control group (black line) and of the rats treated with either RAD001 or a combination of RAD001 and 177Lu-DOTATATE that did not develop metastases (blue line) versus the body weight of rats treated with RAD001 or a combination of RAD001 and 177Lu-DOTATATE that developed metastases (red line).Back to article page