Figure 5
Therapeutic efficiency of combination therapy with [Lys40(Ahx-DTPA-111In)NH 2 ]-exendin-4 and imatinib. (A) The combination of [Lys40(Ahx-DTPA-111In)NH2]-exendin-4 with imatinib has no additive effect on tumor burden (*p < 0.05, Kruskal-Wallis test). (B) The microvessel density is not affected by the (combination) therapy with imatinib. (C) H&E staining of tumor sections after the completion of therapy. Tumor necrosis can be seen under treatment with [Lys40(Ahx-DTPA-111In)NH2]-exendin-4. However, the combination treatment with imatinib does not alter the tumor morphology. (D) The microvessel density is unaffected by treatment with [Lys40(Ahx-DTPA-111In)NH2]-exendin-4 and/or imatinib. Size bars, 100 μm.