Tumor parameters | All tumors (n = 46) | Tumor type | NSCLC subtypeb | |||||
---|---|---|---|---|---|---|---|---|
SCLC (n = 5) | NSCLC (n = 41) | p | Adenocarcinoma (n = 24) | Squamous cell carcinoma (n = 9) | Large cell carcinoma (n = 7) | p | ||
Anatomical characteristics | Â | Â | Â | Â | Â | Â | Â | Â |
 Longest diameter (mm), mean ± SD | 41.1 ± 20.1 | 35.2 ± 18.5 | 42.0 ± 20.9 | 0.70 | 39.9 ± 20.9 | 45.8 ± 21.3 | 37.0 ± 9.9 | 0.80 |
 Location superior/inferior | 83%/17% | 80%/20% | 83%/17% | 0.92 | 87%/13% | 100%/0% | 43%/57% | 0.008 |
 Location central/peripheral | 43%/57% | 80%/20% | 39%/61% | 0.14 | 33%/66% | 66%/33% | 29%/73% | 0.18 |
Clinical characteristics | Â | Â | Â | Â | Â | Â | Â | Â |
 T stage (median (range)) | T2a (T1 to T4b) | T2a (T1b to T4) | T2a (T1a to T4) | 0.84 | T2a (T1a to T4) | T3 (T2a to T4) | T2a (T1b to T2b) | 0.008 |
  T1 | 5 | 1 | 4 |  | 2 | 0 | 2 |  |
  T2 | 29 | 2 | 27 | 18 | 4 | 5 | ||
  T3 | 6 | 1 | 5 | 3 | 2 | 0 | ||
  T4 | 6 | 1 | 5 | 1 | 3 | 0 | ||
 N stage (median (range)) | N1 (N0 to N3) | N2 (N0 to N3) | N1 (N0 to N3) | 0.47 | N2 (N0 to N3) | N1 (N0 to N3) | N0 (N0 to N3) | 0.41 |
  N0 | 15 | 1 | 13 |  | 7 | 1 | 4 |  |
  N1 | 10 | 0 | 11 | 4 | 6 | 1 | ||
  N2 | 9 | 3 | 6 | 5 | 0 | 1 | ||
  N3 | 12 | 1 | 11 | 8 | 2 | 1 | ||
 M stage (median (range)) | M0 (M0 to M1) | M0 (M0) | M0 (M0 to M1) |  | M0 (M0 to M1) | M0 (M0 to M1) | M1 (M0 to M1) | 0.89 |
  M0 | 28 | 5 | 23 | 0.41 | 14 | 6 | 3 |  |
  M1 | 18 | 0 | 18 | 10 | 3 | 4 | ||
 UICC stage (median (range)) | IIIB (IA to IV) | IIIA (IIB to IIIB) | IIIB (IA to IV) | 0.32 | IIIB (IA to IV) | IIIA (IIA to IV) | IV (IB to IV) | 0.88 |
CT-perfusion characteristics | Â | Â | Â | Â | Â | Â | Â | Â |
 Blood flow (mL/100 mL min-1), mean ± SD | 35.5 ± 23.5 | 35.5 ± 12.6 | 35.5 ± 24.3 | 0.67 | 31.4 ± 14.1 | 30.5 ± 9.8 | 56.9 ± 45.7 | 0.21 |
 Blood volume (mL/100 mL), mean ± SD | 8.4 ± 6.4 | 8.6 ± 4.8 | 8.4 ± 6.4 | 0.85 | 9.1 ± 7.4 | 5.3 ± 2.8 | 9.9 ± 5.4 | 0.16 |
 Mean transit time (s), mean ± SD | 14.2 ± 4.5 | 12.4 ± 3.8 | 14.4 ± 4.5 | 0.45 | 14.6 ± 4.4 | 16.3 ± 4.1 | 11.8 ± 4.0 | 0.30 |
18F-FDG-PET/CT characteristics | Â | Â | Â | Â | Â | Â | Â | Â |
 SUVmax (mean ± SD) | 11.7 ± 5.5 | 9.1 ± 3.0 | 12.0 ± 5.6 | 0.35 | 11.3 ± 4.9 | 14.3 ± 5.8 | 9.7 ± 4.8 | 0.28 |
 SUVmean (42%) (mean ± SD) | 7.2 ± 3.3 | 5.8 ± 1.7 | 7.4 ± 3.5 | 0.43 | 6.9 ± 2.9 | 8.9 ± 3.8 | 6.1 ± 3.0 | 0.29 |
 TLG (median (range)) | 120.0 (1.9 to 2621) | 87.8 (7.8 to 232) | 124.3 (1.9 to 2621) | 0.39 | 116.2 (1.9 to 1,900) | 124.3 (30.5 to 1,555) | 101.5 (33.2 to 243.5) | 0.88 |
 PETvol (cm3) (median (range)) | 17.0 (1.2 to 315) | 12.6 (3.1 to 39.6) | 18.2 (1.2 to 315) | 0.58 | 18.1 (1.2 to 315) | 14.1 (3.4 to 68.0) | 18.2 (4.3 to 67.7) | 0.93 |
 PET-positive lymph nodes | 63% | 100% | 59% | 0.14 | 64% | 67% | 43% | 0.59 |
Microvessel densitya (1/mm2), mean ± SD | 149.9 ± 79.7 | - | 149.9 ± 79.7 | - | 155.8 ± 75.9 | 153.7 ± 96.4 | 77.1 | 0.50 |