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Table 5 Agreement between each reader’s interpretation of 5-min-per-view and 10-min-per-view MBI

From: Half-time Tc-99m sestamibi imaging with a direct conversion molecular breast imaging system

  Reader 1 Reader 2
  10 min-per-view vs. 5 min-per-view 10-min-per-view vs. 5-min-per-view WBR   10-min-per-view vs. 5-min-per-view 10-min-per-view vs. 5-min-per-view WBR
No. of breasts Overall agreement (95% CI) κ(95% CI) Overall agreement (95% CI) κ(95% CI) No. of breasts Overall agreement (95% CI) κ(95% CI) Overall agreement (95% CI) κ(95% CI)
Background parenchymal uptake   151/164 (92)
(87, 95)
0.84 (0.76, 0.92) 157/164 (96)
(91, 98)
0.89 (0.81, 0.98)   150/164 (91)
(86, 95)
0.79 (0.69, 0.89) 150/164 (91)
(86, 95)
0.82 (0.73, 0.91)
 Photopenic 24   0.87 (0.75, 0.98)   0.87 (0.75, 0.98) 22   0.82 (0.68, 0.96)   0.77 (0.62, 0.92)
 Mild 124   0.84 (0.75, 0.94)   0.92 (0.84, 0.99) 128   0.81 (0.70, 0.92)   0.79 (0.67, 0.90)
 Moderate 8   0.47 (0.16, 0.78)   0.79 (0.59, 0.99) 8   0.58 (0.31, 0.84)   0.65 (0.39, 0.91)
 Marked 8   0.74 (0.49, 0.98)   1.00 (1.00, 1.00) 6   0.49 (0.07, 0.92)   0.85 (0.65, 1.00)
Lesion type   138/164 (84)
(78, 89)
0.67 (0.56, 0.78) 142/164 (87)
(81, 91)
0.74 (0.63, 0.84)   147/164 (90)
(84, 93)
0.76 (0.65, 0.87) 150/164 (91)
(86, 95)
0.78 (0.68, 0.88)
 No lesion 107   0.75 (0.64, 0.85)   0.83 (0.74, 0.92) 113   0.80 (0.70, 0.90)   0.81 (0.71, 0.91)
 Mass 23   0.61 (0.42, 0.80)   0.69 (0.53, 0.86) 11   0.85 (0.68, 1.00)   0.81 (0.62, 0.99)
 Non-mass 34   0.56 (0.40, 0.72)   0.61 (0.45, 0.76) 40   0.72 (0.59, 0.84)   0.74 (0.62, 0.86)
Distribution of non-mass lesions   137/164 (84)
(77, 88)
0.46 (0.32, 0.61) 139/164 (85)
(78, 89)
0.52 (0.37, 0.66)   147/164 (90)
(84, 93)
0.68 (0.54, 0.82) 149/164 (91)
(85, 94)
0.70 (0.57, 0.84)
 No non-mass lesion 130   0.56 (0.40, 0.72)   0.61 (0.45, 0.76) 124   0.72 (0.59, 0.84)   0.74 (0.64, 0.86)
 Focal area 30   0.48 (0.31, 0.66)   0.52 (0.35, 0.69) 38   0.75 (0.62, 0.87)   0.74 (0.61, 0.86)
 Segmental 2   −0.01 (−0.02,0.00)   0.66 (0.05, 1.00) 1   0.00 (0.00, 0.00)   0.00 (0.00, 0.00)
 Regional 2   −0.02(−0.03,0.00)   −0.01 (−0.03,0.00) 1   0.00 (0.00, 0.00)   0.00 (0.00, 0.00)
 Multiple regions 0   N/A   N/A 0   N/A   N/A
 Diffuse 0   N/A   N/A 0   N/A   N/A
Lesion intensity   139/164 (85)
(78, 89)
0.81 (0.73, 0.89) 145/164 (88)
(83, 93)
0.85 (0.77, 0.92)   143/164 (87)
(81, 91)
0.80 (0.71, 0.88) 146/164 (89)
(83, 93)
0.85 (0.78, 0.92)
 No lesion 107   0.76 (0.65, 0.87)   0.83 (0.74, 0.92) 114   0.78 (0.68, 0.89)   0.87 (0.79, 0.95)
 Photopenic 2   −0.01 (−0.02,0.00)   1.00 (1.00, 1.00) 0   N/A   N/A
 Mild 20   0.46 (0.24, 0.67)   0.58 (0.39, 0.78) 31   0.63 (0.47, 0.78)   0.68 (0.53, 0.83)
 Moderate 22   0.73 (0.57, 0.89)   0.77 (0.62, 0.92) 10   0.68 (0.44, 0.92)   0.53 (0.28, 0.77)
 Marked 13   0.86 (0.70, 1.00)   0.83 (0.67, 0.99) 9   0.87 (0.69, 1.00)   0.94 (0.82, 1.00)
Final assessment of three groups   144/164 (88)
(82, 92)
0.81 (0.73, 0.89) 144/164 (88)
(82, 92)
0.82 (0.75, 0.90)   146/164 (89)
(83, 93)
0.84 (0.76, 0.91) 151/164 (92)
(87, 95)
0.89 (0.82, 0.95)
 Assessment 1 or 2 107   0.80 (0.70, 0.90)   0.82 (0.73, 0.91) 112 0.92 0.81 (0.72, 0.91)   0.87 (0.79, 0.95)
 Assessment 3 17   0.38 (0.14, 0.62)   0.48 (0.27, 0.69) 9 0.91 0.24 (−0.02,0.50)   0.44 (0.17, 0.72)
 Assessment 4 or 5 40   0.83 (0.72, 0.93)   0.82 (0.72, 0.93) 43 0.95 0.87 (0.78, 0.96)   0.90 (0.82, 0.98)
Disease classification   154/164 (94)
(89, 97)
0.83 (0.72, 0.93) 154/164 (94)
(89, 97)
0.82 (0.72, 0.93)   156/164 (95)
(90, 98)
0.87 (0.78, 0.96) 158/164 (96)
(92, 98)
0.90 (0.82, 0.98)
 Test negative: assessment 1 to 3 124   0.83 (0.72, 0.93)   0.82 (0.72, 0.93) 121 0.95 0.87 (0.78, 0.96)   0.90 (0.82, 0.98)
 Test positive: assessment 4 to 5 40   0.83 (0.72, 0.93)   0.82 (0.72, 0.93) 43 0.95 0.87 (0.78, 0.96)   0.90 (0.82, 0.98)
Image quality   55/164 (34)
(27, 41)
0.04 (−0.03, 0.11) 126/164 (77)
(70, 83)
0.12 (−0.01, 0.26)   116/164 (71)
(63, 77)
0.21 (0.09, 0.32) 92/164 (56)
(48, 63)
0.04 (−0.04, 0.13)
 1 - Poor, non-diagnostic 0   N/A   N/A 0   N/A   N/A
 2 - Suboptimal, worse than routine 2   0.16 (−0.04,0.36)   −0.02 (−0.03,0.01) 0   0.00 (0.00, 0.00)   0.00 (0.00, 0.00)
 3 - Acceptable, noisier than routine 11   −0.06 (−0.14,0.01)   0.13 (−0.08,0.33) 14   0.23 (0.08, 0.38)   0.03 (−0.08,0.14)
 4 - Good, same as routine 141   −0.03 (−0.12,0.05)   0.17 (−0.02,0.36) 150   0.24 (0.11, 0.37)   0.05 (−0.05,0.15)
 5 - Excellent, better than routine 10   0.00 (0.00, 0.00)   −0.02 (−0.05,0.00) 0   N/A   N/A
  1. Data are for 82 patients with 164 breasts. Unless otherwise noted, numbers in parentheses are percentages, and percentages are rounded. Number of breasts is those with given feature according to the readers’ interpretations of 10-min-per-view MBI.N/A, kappa statistic was not applicable as no breasts were assigned the given descriptor for any MBI acquisition type.