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EJNMMI Research

Table 5 Agreement between each reader’s interpretation of 5-min-per-view and 10-min-per-view MBI

From: Half-time Tc-99m sestamibi imaging with a direct conversion molecular breast imaging system

 

Reader 1

Reader 2

 

10 min-per-view vs. 5 min-per-view

10-min-per-view vs. 5-min-per-view WBR

 

10-min-per-view vs. 5-min-per-view

10-min-per-view vs. 5-min-per-view WBR

No. of breasts

Overall agreement (95% CI)

κ(95% CI)

Overall agreement (95% CI)

κ(95% CI)

No. of breasts

Overall agreement (95% CI)

κ(95% CI)

Overall agreement (95% CI)

κ(95% CI)

Background parenchymal uptake

 

151/164 (92)

(87, 95)

0.84 (0.76, 0.92)

157/164 (96)

(91, 98)

0.89 (0.81, 0.98)

 

150/164 (91)

(86, 95)

0.79 (0.69, 0.89)

150/164 (91)

(86, 95)

0.82 (0.73, 0.91)

 Photopenic

24

 

0.87 (0.75, 0.98)

 

0.87 (0.75, 0.98)

22

 

0.82 (0.68, 0.96)

 

0.77 (0.62, 0.92)

 Mild

124

 

0.84 (0.75, 0.94)

 

0.92 (0.84, 0.99)

128

 

0.81 (0.70, 0.92)

 

0.79 (0.67, 0.90)

 Moderate

8

 

0.47 (0.16, 0.78)

 

0.79 (0.59, 0.99)

8

 

0.58 (0.31, 0.84)

 

0.65 (0.39, 0.91)

 Marked

8

 

0.74 (0.49, 0.98)

 

1.00 (1.00, 1.00)

6

 

0.49 (0.07, 0.92)

 

0.85 (0.65, 1.00)

Lesion type

 

138/164 (84)

(78, 89)

0.67 (0.56, 0.78)

142/164 (87)

(81, 91)

0.74 (0.63, 0.84)

 

147/164 (90)

(84, 93)

0.76 (0.65, 0.87)

150/164 (91)

(86, 95)

0.78 (0.68, 0.88)

 No lesion

107

 

0.75 (0.64, 0.85)

 

0.83 (0.74, 0.92)

113

 

0.80 (0.70, 0.90)

 

0.81 (0.71, 0.91)

 Mass

23

 

0.61 (0.42, 0.80)

 

0.69 (0.53, 0.86)

11

 

0.85 (0.68, 1.00)

 

0.81 (0.62, 0.99)

 Non-mass

34

 

0.56 (0.40, 0.72)

 

0.61 (0.45, 0.76)

40

 

0.72 (0.59, 0.84)

 

0.74 (0.62, 0.86)

Distribution of non-mass lesions

 

137/164 (84)

(77, 88)

0.46 (0.32, 0.61)

139/164 (85)

(78, 89)

0.52 (0.37, 0.66)

 

147/164 (90)

(84, 93)

0.68 (0.54, 0.82)

149/164 (91)

(85, 94)

0.70 (0.57, 0.84)

 No non-mass lesion

130

 

0.56 (0.40, 0.72)

 

0.61 (0.45, 0.76)

124

 

0.72 (0.59, 0.84)

 

0.74 (0.64, 0.86)

 Focal area

30

 

0.48 (0.31, 0.66)

 

0.52 (0.35, 0.69)

38

 

0.75 (0.62, 0.87)

 

0.74 (0.61, 0.86)

 Segmental

2

 

−0.01 (−0.02,0.00)

 

0.66 (0.05, 1.00)

1

 

0.00 (0.00, 0.00)

 

0.00 (0.00, 0.00)

 Regional

2

 

−0.02(−0.03,0.00)

 

−0.01 (−0.03,0.00)

1

 

0.00 (0.00, 0.00)

 

0.00 (0.00, 0.00)

 Multiple regions

0

 

N/A

 

N/A

0

 

N/A

 

N/A

 Diffuse

0

 

N/A

 

N/A

0

 

N/A

 

N/A

Lesion intensity

 

139/164 (85)

(78, 89)

0.81 (0.73, 0.89)

145/164 (88)

(83, 93)

0.85 (0.77, 0.92)

 

143/164 (87)

(81, 91)

0.80 (0.71, 0.88)

146/164 (89)

(83, 93)

0.85 (0.78, 0.92)

 No lesion

107

 

0.76 (0.65, 0.87)

 

0.83 (0.74, 0.92)

114

 

0.78 (0.68, 0.89)

 

0.87 (0.79, 0.95)

 Photopenic

2

 

−0.01 (−0.02,0.00)

 

1.00 (1.00, 1.00)

0

 

N/A

 

N/A

 Mild

20

 

0.46 (0.24, 0.67)

 

0.58 (0.39, 0.78)

31

 

0.63 (0.47, 0.78)

 

0.68 (0.53, 0.83)

 Moderate

22

 

0.73 (0.57, 0.89)

 

0.77 (0.62, 0.92)

10

 

0.68 (0.44, 0.92)

 

0.53 (0.28, 0.77)

 Marked

13

 

0.86 (0.70, 1.00)

 

0.83 (0.67, 0.99)

9

 

0.87 (0.69, 1.00)

 

0.94 (0.82, 1.00)

Final assessment of three groups

 

144/164 (88)

(82, 92)

0.81 (0.73, 0.89)

144/164 (88)

(82, 92)

0.82 (0.75, 0.90)

 

146/164 (89)

(83, 93)

0.84 (0.76, 0.91)

151/164 (92)

(87, 95)

0.89 (0.82, 0.95)

 Assessment 1 or 2

107

 

0.80 (0.70, 0.90)

 

0.82 (0.73, 0.91)

112

0.92

0.81 (0.72, 0.91)

 

0.87 (0.79, 0.95)

 Assessment 3

17

 

0.38 (0.14, 0.62)

 

0.48 (0.27, 0.69)

9

0.91

0.24 (−0.02,0.50)

 

0.44 (0.17, 0.72)

 Assessment 4 or 5

40

 

0.83 (0.72, 0.93)

 

0.82 (0.72, 0.93)

43

0.95

0.87 (0.78, 0.96)

 

0.90 (0.82, 0.98)

Disease classification

 

154/164 (94)

(89, 97)

0.83 (0.72, 0.93)

154/164 (94)

(89, 97)

0.82 (0.72, 0.93)

 

156/164 (95)

(90, 98)

0.87 (0.78, 0.96)

158/164 (96)

(92, 98)

0.90 (0.82, 0.98)

 Test negative: assessment 1 to 3

124

 

0.83 (0.72, 0.93)

 

0.82 (0.72, 0.93)

121

0.95

0.87 (0.78, 0.96)

 

0.90 (0.82, 0.98)

 Test positive: assessment 4 to 5

40

 

0.83 (0.72, 0.93)

 

0.82 (0.72, 0.93)

43

0.95

0.87 (0.78, 0.96)

 

0.90 (0.82, 0.98)

Image quality

 

55/164 (34)

(27, 41)

0.04 (−0.03, 0.11)

126/164 (77)

(70, 83)

0.12 (−0.01, 0.26)

 

116/164 (71)

(63, 77)

0.21 (0.09, 0.32)

92/164 (56)

(48, 63)

0.04 (−0.04, 0.13)

 1 - Poor, non-diagnostic

0

 

N/A

 

N/A

0

 

N/A

 

N/A

 2 - Suboptimal, worse than routine

2

 

0.16 (−0.04,0.36)

 

−0.02 (−0.03,0.01)

0

 

0.00 (0.00, 0.00)

 

0.00 (0.00, 0.00)

 3 - Acceptable, noisier than routine

11

 

−0.06 (−0.14,0.01)

 

0.13 (−0.08,0.33)

14

 

0.23 (0.08, 0.38)

 

0.03 (−0.08,0.14)

 4 - Good, same as routine

141

 

−0.03 (−0.12,0.05)

 

0.17 (−0.02,0.36)

150

 

0.24 (0.11, 0.37)

 

0.05 (−0.05,0.15)

 5 - Excellent, better than routine

10

 

0.00 (0.00, 0.00)

 

−0.02 (−0.05,0.00)

0

 

N/A

 

N/A

  1. Data are for 82 patients with 164 breasts. Unless otherwise noted, numbers in parentheses are percentages, and percentages are rounded. Number of breasts is those with given feature according to the readers’ interpretations of 10-min-per-view MBI.N/A, kappa statistic was not applicable as no breasts were assigned the given descriptor for any MBI acquisition type.
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