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Table 3 Lesions that were test positive on 10-min-per-view MBI but test negative on 5-min-per-view MBI

From: Half-time Tc-99m sestamibi imaging with a direct conversion molecular breast imaging system

  Lesion histopathology Size (cm) Grade Node status Lesion intensity Image count density Reader 1 Reader 2
5-min-per-view assessmenta 5-min-per-view WBR assessmenta 5-min-per-view assessmenta 5-min-per-view WBR assessmenta
Patient number           
 1 Invasive ductal carcinoma 0.9 III N0 Mild High 3 3 1 3
 2 Invasive ductal carcinoma 1.8 II N0 Moderate Intermediate 3 3 3 (4)
 3 Invasive ductal carcinoma 2.5 I N1mi Mild Intermediate 3 (4) (4) (4)
 4 Invasive ductal carcinoma 0.5 III N1 Mild High 2 2 2 2
 5 Invasive ductal carcinoma 2.0 II N0 Mild Intermediate 3 3 (4) 3
 6 Mucinous carcinoma 1.1 I N0 Mild Intermediate 3 3 (4) 3
 7 Atypical ductal hyperplasia 0.9 - - Mild Intermediate (4) 3 3 3
 8 Benign fibrocystic changes 0.4 - - Mild Intermediate 1 1 1 1
 9 Benign fibrocystic changes 1.8 - - Moderate High 3 3 (4) 3
 10 Fibroadenoma 0.8 - - Mild High 2 1 1 2
 11 Fibroadenoma 1.0 - - Mild Intermediate 1 3 3 3
 12 Benign breast parenchyma 3.0 - - Mild High 1 1 1 3
 13 Benign lymph node 0.8 - - Mild Low (4) 3 3 (4)
 14 Benign breast parenchyma 1.1 - - Mild High 1 3 3 (4)
 15 Benign lymph node 1.5 - - Moderate Intermediate 3 3 3 (4)
No. of patients with assessment 3 7 10 6 7
No. of patients with assessment 1 or 2 6 4 5 3
  1. Assessments of 4 or 5 were considered test positive; assessments of ≤3 were considered test negative. aFinal assessment is given for lesions detected by either reader on 10-min-per-view acquisitions but not detected by at least one reader on 5 min-per-view or 5-min-per-view WBR acquisitions. Assessments in parentheses indicate a detected lesion. Lesion size and intensity classification was determined at case selection based on the clinically-interpreted MBI report of the 10-min-per-view acquisitions. Image count density was measured in the background (non-lesion) region of benign breast tissue on the 10-min-per-view MBI acquisition. Count density was defined as low (<1,150 counts/cm2), intermediate (1,150 to1,750 counts/cm2), or high (>1,750 counts/cm2). Note: in one additional patient, a benign lesion was considered undetected at 10 min-per-view (assessment = 3) but was detected at 5 min-per-view and 5 min-per-view with WBR (assessment of 4) by reader 1.