Half-time Tc-99m sestamibi imaging with a direct conversion molecular breast imaging system

EJNMMI Research

Table 3 Lesions that were test positive on 10-min-per-view MBI but test negative on 5-min-per-view MBI

	Lesion histopathology	Size (cm)	Grade	Node status	Lesion intensity	Image count density	Reader 1		Reader 2
	Lesion histopathology	Size (cm)	Grade	Node status	Lesion intensity	Image count density	5-min-per-view assessment^a	5-min-per-view WBR assessment^a	5-min-per-view assessment^a	5-min-per-view WBR assessment^a
Patient number
1	Invasive ductal carcinoma	0.9	III	N0	Mild	High	3	3	1	3
2	Invasive ductal carcinoma	1.8	II	N0	Moderate	Intermediate	3	3	3	(4)
3	Invasive ductal carcinoma	2.5	I	N1mi	Mild	Intermediate	3	(4)	(4)	(4)
4	Invasive ductal carcinoma	0.5	III	N1	Mild	High	2	2	2	2
5	Invasive ductal carcinoma	2.0	II	N0	Mild	Intermediate	3	3	(4)	3
6	Mucinous carcinoma	1.1	I	N0	Mild	Intermediate	3	3	(4)	3
7	Atypical ductal hyperplasia	0.9	-	-	Mild	Intermediate	(4)	3	3	3
8	Benign fibrocystic changes	0.4	-	-	Mild	Intermediate	1	1	1	1
9	Benign fibrocystic changes	1.8	-	-	Moderate	High	3	3	(4)	3
10	Fibroadenoma	0.8	-	-	Mild	High	2	1	1	2
11	Fibroadenoma	1.0	-	-	Mild	Intermediate	1	3	3	3
12	Benign breast parenchyma	3.0	-	-	Mild	High	1	1	1	3
13	Benign lymph node	0.8	-	-	Mild	Low	(4)	3	3	(4)
14	Benign breast parenchyma	1.1	-	-	Mild	High	1	3	3	(4)
15	Benign lymph node	1.5	-	-	Moderate	Intermediate	3	3	3	(4)
No. of patients with assessment 3							7	10	6	7
No. of patients with assessment 1 or 2							6	4	5	3

Assessments of 4 or 5 were considered test positive; assessments of ≤3 were considered test negative. ^aFinal assessment is given for lesions detected by either reader on 10-min-per-view acquisitions but not detected by at least one reader on 5 min-per-view or 5-min-per-view WBR acquisitions. Assessments in parentheses indicate a detected lesion. Lesion size and intensity classification was determined at case selection based on the clinically-interpreted MBI report of the 10-min-per-view acquisitions. Image count density was measured in the background (non-lesion) region of benign breast tissue on the 10-min-per-view MBI acquisition. Count density was defined as low (<1,150 counts/cm²), intermediate (1,150 to1,750 counts/cm²), or high (>1,750 counts/cm²). Note: in one additional patient, a benign lesion was considered undetected at 10 min-per-view (assessment = 3) but was detected at 5 min-per-view and 5 min-per-view with WBR (assessment of 4) by reader 1.