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Figure 1 | EJNMMI Research

Figure 1

From: The La antigen is over-expressed in lung cancer and is a selective dead cancer cell target for radioimmunotherapy using the La-specific antibody APOMAB®

Figure 1

Expression of La mRNA and protein in lung cancer. (A) The expression of La mRNA in normal compared to lung cancer samples was examined using the online database Oncomine. Two studies showed increased La mRNA expression in lung cancer samples compared to normal lung tissue. Data was taken from (I) Hou et al.’s study[30] and (II) Landi et al.’s study[29]. Data are shown with 95% confidence intervals and circles representing outliers. LCLC, large cell lung cancer; SCC, squamous cell lung cancer; AC, adenocarcinoma. *** p < 0.001. (B) Photomicrographs of DAB4 staining pattern in sections of resected human lung tumours. TissueFocus Cancer Survery Tissue Microarray (Origene) was examined via immunohistochemistry for DAB4 expression. (I) Poorly differentiated squamous cell carcinoma of bronchus (case No. 0000019032): tumour cells (T); hypocellular stroma (S) with variable DAB4 expression (evident as brown staining) of normal cells including endothelial cells and other stromal cells (arrowheads). (II) Adenosquamous carcinoma (case No. 0000016518): predominantly basaloid squamous cell carcinoma (T) with prominent DAB4-stained nucleoli (arrowheads); desmoplastic stromal reaction (S) with both DAB4-stained and unstained nuclei of stromal cells (arrow). (III) Poorly differentiated adenocarcinoma (case No. 0000008378): acinar structures (A) are evidently interweaved with a hypercellular stroma (S). Some malignant cells were not stained with DAB4 (arrowheads). (IV) Poorly differentiated lung adenocarcinoma (case No. 0000016267): the high-grade malignant cells (T) are vacuolated and have weak non-specific cytoplasmic staining with DAB4 (arrowheads); a desmoplastic stromal reaction (S) with DAB4-stained lymphoplasmacytic infiltrates (arrows). (V and VI) Normal lung tissue (case No. 0000000144 and 0000006853) showed reduced, predominantly nuclear DAB4 staining. All sections are shown at × 20 magnification, and scale bars are indicated.

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