Figure 5

Comparison of [¹⁸F]FDG and [⁶⁸Ga]GaCl ₃ imaging of the vasculature in mice. (a) CLI using [¹⁸F]FDG on a day-14 fibrosarcoma tumor with corresponding photographic image below. (b) CLI using [⁶⁸Ga]GaCl₃ for a day-14 fibrosarcoma tumor with corresponding photographic image below. The tumors are outlined in red. A blood vessel can be seen in the [¹⁸F]FDG image, resulting in a 6% reduction in radiance outside the tumor and 12% reduction in the tumor core. However, the vasculature is much clearer and more elaborate in the [⁶⁸Ga]GaCl₃ image, where the blood vessel in the tumor attenuated 9% of the Cerenkov light and the tumor core attenuated 18% of the Cerenkov light.