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Table 4 Percentage of the unchanged form in organs and associated sample recovery of 18 F-SIG343 and 18 F-SIG353

From: Synthesis and biological characterisation of 18F-SIG343 and 18F-SIG353, novel and high selectivity σ2 radiotracers, for tumour imaging properties

Compound Time (min) Unchanged form (%) a[sample recovery (%)] b
Tumour Cortex Plasma Urine
18F-SIG343 15 79 ± 4.6 (86) 87 ± 3.2 (92) 49 ± 7.5 (89 ± 14.4) 13 ± 1.2
60 85 ± 3.1 (90) 83 ± 0.8 (88) 23 ± 3.8 (86 ± 16.4) 15 ± 4.3
120 80 ± 5.0 (86) 86 ± 1.0 (90) 16 ± 2.8 (91 ± 9.0) 11 ± 5.4
18F-SIG353 15 81 ± 4.5 (86) 85 (91) 60 ± 3.0 (92 ± 6.8) 5 ± 1.3
60 85 ± 2.4 (90) 87 (93) 27 ± 5.1 (88 ± 10.7) 4 ± 0.4
120 65 ± 8.9 (81) IR 17 ± 2.9 (94 ± 5.3) 5 ± 1.2
  1. aMeans ± SD (n =3); bthe recovery of the radioactivity. IR insufficient radioactivity for analysis.