Compound | Time (min) | Unchanged form (%) a[sample recovery (%)] b | |||
---|---|---|---|---|---|
Tumour | Cortex | Plasma | Urine | ||
18F-SIG343 | 15 | 79 ± 4.6 (86) | 87 ± 3.2 (92) | 49 ± 7.5 (89 ± 14.4) | 13 ± 1.2 |
60 | 85 ± 3.1 (90) | 83 ± 0.8 (88) | 23 ± 3.8 (86 ± 16.4) | 15 ± 4.3 | |
120 | 80 ± 5.0 (86) | 86 ± 1.0 (90) | 16 ± 2.8 (91 ± 9.0) | 11 ± 5.4 | |
18F-SIG353 | 15 | 81 ± 4.5 (86) | 85 (91) | 60 ± 3.0 (92 ± 6.8) | 5 ± 1.3 |
60 | 85 ± 2.4 (90) | 87 (93) | 27 ± 5.1 (88 ± 10.7) | 4 ± 0.4 | |
120 | 65 ± 8.9 (81) | IR | 17 ± 2.9 (94 ± 5.3) | 5 ± 1.2 |