Skip to main content

Table 4 Percentage of the unchanged form in organs and associated sample recovery of 18 F-SIG343 and 18 F-SIG353

From: Synthesis and biological characterisation of 18F-SIG343 and 18F-SIG353, novel and high selectivity σ2 radiotracers, for tumour imaging properties

Compound

Time (min)

Unchanged form (%) a[sample recovery (%)] b

Tumour

Cortex

Plasma

Urine

18F-SIG343

15

79 ± 4.6 (86)

87 ± 3.2 (92)

49 ± 7.5 (89 ± 14.4)

13 ± 1.2

60

85 ± 3.1 (90)

83 ± 0.8 (88)

23 ± 3.8 (86 ± 16.4)

15 ± 4.3

120

80 ± 5.0 (86)

86 ± 1.0 (90)

16 ± 2.8 (91 ± 9.0)

11 ± 5.4

18F-SIG353

15

81 ± 4.5 (86)

85 (91)

60 ± 3.0 (92 ± 6.8)

5 ± 1.3

60

85 ± 2.4 (90)

87 (93)

27 ± 5.1 (88 ± 10.7)

4 ± 0.4

120

65 ± 8.9 (81)

IR

17 ± 2.9 (94 ± 5.3)

5 ± 1.2

  1. aMeans ± SD (n =3); bthe recovery of the radioactivity. IR insufficient radioactivity for analysis.