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Table 2 In vitro characteristics of SIG343 and SIG353

From: Synthesis and biological characterisation of 18F-SIG343 and 18F-SIG353, novel and high selectivity σ2 radiotracers, for tumour imaging properties

Parameters Compound
SIG343 SIG353
Affinity (nM)   
σ1 a 1,600 266
σ2 a 8 2.4
Opioid, non-selectiveb >104 >104
Dopamine, non-selectiveb >104 >104
Serotonin, non-selectiveb >104 >104
CB1, non-selectiveb >104 >104
Muscarinic, non-selectiveb >104 >104
Selectivity   
σ21 200 110
Lipophilicity   
LogPb 3.11 ± 0.08 3.47 ± 0.09
  1. a K i, determined by ANSTO LifeSciences; b IC 50, determined by Caliper LifeSciences.