Time-activity curves of 18
F-SIG343 (a) and 18
F-SIG353 (b) in selected organs. Results were expressed as Activity (%ID/cc) over Time (min) (means ± SD, n = 3). Mice were injected intravenously with 4.6-16.7 MBq of 18F-SIG343 or 18F-SIG353, with a constant tracer mass of the unlabelled compound of 0.06 nmol/100 μL of saline. A 120-min PET scan was performed on an Inveon PET/CT system, followed by a 10-min CT scan on each subject for anatomical information.