Kinetic analysis of [11C]befloxatone in the human brain, a selective radioligand to image monoamine oxidase A

EJNMMI Research

Table 1 Distribution volume calculated from compartmental modeling, Logan plot, MA1, and SA using regions or individual voxels

Region	V _T(mL/cm ³)
	Region				Voxel
	Unconstrained two-tissue compartment model	Logan	MA1	SA	Logan	SA
Frontal cortex	13.3 ± 0.84 (2.7)	12.5 ± 0.79	11.8 ± 0.71	13.6 ± 1.21	8.66 ± 2.14	13.7 ± 0.90
Temporal cortex	15.1 ± 1.04 (2.6)	14.1 ± 0.90	13.5 ± 0.83	15.3 ± 0.85	9.69 ± 2.64	15.4 ± 0.97
Hippocampus	16.2 ± 1.11 (6.9)	14.8 ± 1.09	13.8 ± 0.75	15.2 ± 1.74	6.36 ± 1.87	14.4 ± 1.79
Parietal cortex	13.0 ± 0.61 (2.8)	12.3 ± 0.53	11.6 ± 0.40	13.3 ± 0.94	8.59 ± 2.20	13.5 ± 1.10
Occipital cortex	15.4 ± 1.08 (2.8)	14.4 ± 0.99	13.6 ± 0.83	15.5 ± 1.20	9.87 ± 2.19	15.7 ± 1.13
Anterior cingulum	16.2 ± 1.56 (4.6)	15.2 ± 1.43	14.7 ± 1.20	16.9 ± 2.02	9.94 ± 2.56	16.2 ± 0.90
Caudate	12.5 ± 1.20 (7.7)	11.4 ± 1.00	11.0 ± 0.73	12.4 ± 1.21	7.17 ± 1.94	13.0 ± 1.36
Putamen	14.8 ± 0.67 (3.8)	13.9 ± 0.77	13.3 ± 0.70	15.2 ± 0.80	10.3 ± 3.00	16.5 ± 0.99
Thalamus	19.3 ± 1.43 (5.6)	17.7 ± 1.69	16.5 ± 1.18	19.5 ± 2.33	10.1 ± 3.11	19.0 ± 2.32
Cerebellum	6.73 ± 0.91 (2.5)	6.42 ± 0.82	6.18 ± 0.75	6.83 ± 0.95	5.19 ± 1.98	7.58 ± 0.86

Values are presented as mean ± SD from seven human subjects. For each brain region, standard errors are listed in parentheses and are expressed as the percentage of the variable itself.