Figure 7
Effects of k 3 change in the reference region on k 3 bias in 40-min 3P++ analysis. Simulated target TACs were generated by 4P model with two different k 3 values (0.018/min for NC, open circle; 0.036/min for AD, closed circle). Simulated reference TACs were generated by 3P model with five different k 3 values (0 to 0.008/min). The k 3 bias in 3P++ analysis was expressed relative to 3P + analysis as bias (%) = (3P++ k 3/3P + k 3 – 1) × 100. Effects on bias in 3P++ k 3′ relative to 3P + k 3 are also shown (NC, open triangle; AD, closed triangle), where 3P++ k 3′ was calculated as (3P++ k 3′) = (3P++ k 3) + reference k 3.