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Table 2 Proportion of simulations that had the number of components underestimated, overestimated or correctly estimated by NLSA and SA

From: Assessing radiotracer kinetics in the Langendorff perfused heart

Simulated scenario NLSA performance SA performance
SNR = 60 SNR = 120 SNR = 60 SNR = 120
UE (%) OE (%) CE (%) UE (%) OE (%) CE (%) UE (%) OE (%) CE (%) UE (%) OE (%) CE (%)
Tri-exponential             
  No trapping (α 0 = 0) 85 - 15 0 - 100 - 81a 19a - 100a 0a
  Trapping 1 (α 0 = 0.006) 100 - 0 46 - 54 18 - 82 - - 100
  Trapping 2 (α 0 = 0.06) 100 - 0 60 - 40 18 - 82 - - 100
  Trapping 3 (α 0 = 0.2) 100 - 0 95 - 5 46 - 54 - - 100
  Trapping 4 (α 0 = 0.6) 100 - 0 100 - 0 53 - 47 1 - 99
Bi-exponential             
  No trapping (α 0 = 0) - - 100 - - 100 - 86a 14a - - 100a
  Trapping 1 (α 0 = 0.006) 1 - 99 - - 100 17 18 65 - - 100
  Trapping 2 (α 0 = 0.06) 1 - 99 - - 100 - - 100 - - 100
  Trapping 3 (α 0 = 0.2) 11 - 89 5 - 95 - - 100 - - 100
  Trapping 4 (α 0 = 0.6) 34 - 66 32 - 68 - - 100 - - 100
  1. α 0 indicates the tracer trapping. Units are in min-1; UE, underestimated number of components; OE, overestimated number of components; CE, correctly estimated. Results are shown only for the percentage of datasets where the presence of baseline was correctly estimated (Table 1). aAn accuracy in baseline identification was <25%.