EJNMMI Research

Table 2 Proportion of simulations that had the number of components underestimated, overestimated or correctly estimated by NLSA and SA

From: Assessing radiotracer kinetics in the Langendorff perfused heart

Simulated scenario	NLSA performance						SA performance
	SNR = 60			SNR = 120			SNR = 60			SNR = 120
	UE (%)	OE (%)	CE (%)	UE (%)	OE (%)	CE (%)	UE (%)	OE (%)	CE (%)	UE (%)	OE (%)	CE (%)
Tri-exponential
No trapping (α ₀ = 0)	85	-	15	0	-	100	-	81^a	19^a	-	100^a	0^a
Trapping 1 (α ₀ = 0.006)	100	-	0	46	-	54	18	-	82	-	-	100
Trapping 2 (α ₀ = 0.06)	100	-	0	60	-	40	18	-	82	-	-	100
Trapping 3 (α ₀ = 0.2)	100	-	0	95	-	5	46	-	54	-	-	100
Trapping 4 (α ₀ = 0.6)	100	-	0	100	-	0	53	-	47	1	-	99
Bi-exponential
No trapping (α ₀ = 0)	-	-	100	-	-	100	-	86^a	14^a	-	-	100^a
Trapping 1 (α ₀ = 0.006)	1	-	99	-	-	100	17	18	65	-	-	100
Trapping 2 (α ₀ = 0.06)	1	-	99	-	-	100	-	-	100	-	-	100
Trapping 3 (α ₀ = 0.2)	11	-	89	5	-	95	-	-	100	-	-	100
Trapping 4 (α ₀ = 0.6)	34	-	66	32	-	68	-	-	100	-	-	100

α ₀ indicates the tracer trapping. Units are in min^-1; UE, underestimated number of components; OE, overestimated number of components; CE, correctly estimated. Results are shown only for the percentage of datasets where the presence of baseline was correctly estimated (Table 1). ^aAn accuracy in baseline identification was <25%.

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