Figure 3

Effect of antioxidants on bortezomib-induced clonogenic cell kill. Clonogenic assay of (A) SK-N-BE(2c) and (B) UVW/NAT cells exposed to bortezomib for 24 h in the presence or absence of the antioxidants NAC (1 mM) or tiron (1 mM). Data are means ± SEM, n = 4; significance of differences: ** p < 0.01 from untreated control, † p < 0.05, †† p < 0.01 from bortezomib treatment alone.