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Table 3 Overview of diagnostic values obtained by tested assessment approaches

From: Explorative analyses on the value of interim PET for prediction of response in pediatric and adolescent non-Hodgkin lymphoma patients

  Assessment approach
  iCIM iPET ΔSUVmax
TP (n) 1 3 3
FP (n) 2 6 4
TN (n) 10 6 8
FN (n) 3 1 1
Sensitivity, % (CI) 25.0 75.0 75.0
  (1.3-70.0) (30.1-98.7) (30.1-98.7)
Specificity, % (CI) 83.3 50.0 66.7
  (55.2-95.3) (25.4-74.6) (39.1-86.2)
PPV, % (CI) 33.3 33.3 42.9
  (1.7-79.2) (12.1-64.6) (15.8-75.0)
NPV, % (CI) 76.9 85.7 88.9
  (49.7-91.8) (48.7-99.3) (56.5-99.4)
Accuracy, % (CI) 68.8 56.2 68.8
  (44.4-85.8) (33.2-76.9) (44.4-85.8)
  1. Δ, percentaged decrease of SUVmax between staging and restaging; CI, confidence interval; FN, false-negative; FP, false-positive; iCIM, conventional imaging modalities performed at interim; iPET, positron emission tomography performed at interim; n, count; NPV, negative predictive value; PPV, positive predictive value; SUVmax, maximum standardized uptake value; TN, true-negative; TP, true-positive.