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Table 3 Overview of diagnostic values obtained by tested assessment approaches

From: Explorative analyses on the value of interim PET for prediction of response in pediatric and adolescent non-Hodgkin lymphoma patients

 

Assessment approach

 

iCIM

iPET

ΔSUVmax

TP (n)

1

3

3

FP (n)

2

6

4

TN (n)

10

6

8

FN (n)

3

1

1

Sensitivity, % (CI)

25.0

75.0

75.0

 

(1.3-70.0)

(30.1-98.7)

(30.1-98.7)

Specificity, % (CI)

83.3

50.0

66.7

 

(55.2-95.3)

(25.4-74.6)

(39.1-86.2)

PPV, % (CI)

33.3

33.3

42.9

 

(1.7-79.2)

(12.1-64.6)

(15.8-75.0)

NPV, % (CI)

76.9

85.7

88.9

 

(49.7-91.8)

(48.7-99.3)

(56.5-99.4)

Accuracy, % (CI)

68.8

56.2

68.8

 

(44.4-85.8)

(33.2-76.9)

(44.4-85.8)

  1. Δ, percentaged decrease of SUVmax between staging and restaging; CI, confidence interval; FN, false-negative; FP, false-positive; iCIM, conventional imaging modalities performed at interim; iPET, positron emission tomography performed at interim; n, count; NPV, negative predictive value; PPV, positive predictive value; SUVmax, maximum standardized uptake value; TN, true-negative; TP, true-positive.