Figure 3

Fourteen-year-old boy suffering from Burkitt-lymphoma (Table 2 , patient 15). The lymphoma was primarily localized in the stomach (A, B, C). Initial SUVmax was 21.5 and decreased to 10.6 at interim time point (A and D; Δ SUVmax, 50.7%). Also, in the visual iPET analysis (D), the patient was judged to be positive (please note activation of brown adipose tissue at interim marked with black arrow heads (D). Using CIM, a decrease of 100% between baseline (arrows in B and C) and interim time points was shown (arrow heads in E and F). No further measurable disease was detected by CIM. Thus, a complete response was indicated by CIM. The patient is in ongoing remission. Therefore, both Δ SUVmax and visual iPET analyses were false-positive when compared to true outcome, whereas CIM was true-negative.