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EJNMMI Research

Table 1 Results of the CuAAC reaction for different catalysts and heating conditions

From: 18 F-click labeling and preclinical evaluation of a new 18 F-folate for PET imaging

 

Cu(I)I (%)

Cu(I)I + sodium

Cu(II)acetate + sodium

Cu(II)sulfate + sodium

ascorbate (%)

ascorbate (%)

ascorbate (%)

Microwavea

60 ± 3

22

45

n.d.

Oil bathb

20

n.d.

30

15

  1. For all reactions, the used copper concentration was kept constant, whereby that for reactions using copper(II) ascorbate was used in tenfold excess. Yields were determined by HPLC, and for the superior conditions, n = 3. aPerformed at 110°C for 10 min and a mode with 1-min pre-run and a maximum power of 300 W; bperformed at 65°C. n.d., no data.
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