Scheme 2
From: 18 F-click labeling and preclinical evaluation of a new 18 F-folate for PET imaging
Synthesis of the prosthetic group precursor (10), followed by radiosynthesis of the 18F-labeled prosthetic group [18F]11 and 18F-labeled radiofolate [18F]12.
Synthesis of the prosthetic group precursor (10), followed by radiosynthesis of the18 F-labeled prosthetic group [18 F]11 and18 F-labeled radiofolate [18 F]12. (a) DCM, TEA, Tos-Cl, rt. (b) TBA-OH, acetonitrile, 110°C. (c) Cu(II)acetate, sodium ascorbate, 110°C, acetonitrile/water/0.05 M phosphate buffer.