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EJNMMI Research
Figure 1 | EJNMMI Research

Figure 1

From: Comparison between kinetic modelling and graphical analysis for the quantification of [18F]fluoromethylcholine uptake in mice

Figure 1

Visual representation of the different kinetic models. (a) Schematic of a two-tissue-compartment model with one input function (2C1i). Transfer coefficients K 1 and k 2 describe the uptake and washout of the free tracer and its metabolite ([18F]FBet) across cell membranes. Rate constant k 3 is regarded as the conversion of [18F]FCho into [18F]FPCho, which is assumed to be metabolically trapped in the cell. Micro-parameter k 4 represents dephosphorylation and is expected to be very small. (b) Schematic of a three-tissue-compartment model with two input functions (3C2i). Rate constants K 1p and K 1m, or k 2p and k 2m represent respectively the uptake and washout of [18F]FCho and [18F]FBet.

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