CADO treatment limits cardiomyocyte hypertrophy. Upper panel: representative histological sections stained with haematoxylin and eosin in remote areas showing cardiomyocyte hypertrophy. Lower panel: quantitative analysis of the cross-sectional area of cardiomyocytes from remote areas. Cardiomyocyte hypertrophy was decreased in CADO-treated rats compared to control rats. Results are mean ± SEM. au, arbitrary units. *p < 0.005; **p < 0.001. Magnification, ×400.