Kinetics of 18
F-MK-9470 in a bone metastasis. 18F-MK-9470 uptake in a lesion of the left femoral head versus 18F-MK-9470 uptake in contralateral normal bone tissue of patient 5 (A). The DWI MRI (B) and the T2w MRI (C) images show a low-signal-intensity mass in the lesion of the left femoral head as well as the local tumour (indicated with an asterisk). Integrated PET images of the first (D), second (E) and third (F) acquisition time interval demonstrate increased 18F-MK-9470 uptake in the bone metastasis as compared to that of the contralateral bone. Note the absence of 18F-MK-9470 uptake in the local PCa visible on the MRI images. Data are scaled from 0 to 4.5 SUV in (C) and scaled form 0 to 3.0 SUV in (D) and (E).