Figure 2From: Synthesis and evaluation of [11C]MMPIP as a potential radioligand for imaging of metabotropic glutamate 7 receptor in the brain Chemical synthesis and radiosynthesis. (a) Lithium bis(trimethysilyl)amide in hexane, THF, −40°C, 30 min then room temperature, overnight. (b) Bu4NF, THF, room temperature, overnight. (c) p-Toluenesulfonic acid monohydrate, 1,4-dioxane, reflux, 12 h. (d) DMF, NaOH, 80°C, 3 min.Back to article page