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Table 4 Number of operations required to synthesize common probes

From: Simplified programming and control of automated radiosynthesizers through unit operations

System

Probe

Operation count

ELIXYS

[18F]FDG

18 unit operations

ELIXYS

d-[18F]FAC

42 unit operations

ELIXYS

l-[18F]FMAU

42 unit operations

ELIXYS

[18F]SFB

15 unit operations

ELIXYS

[18F]FLT

15 unit operations

ELIXYS

[18F]Fallypride

12 unit operations

Synthera

[18F]FDG

227 program steps

Synthera

[18F]FLTa

241 program steps

Synthera

[18F]SFBa

206 program steps

FASTlab

[18F]FDG

335 program steps

Explora RN

[18F]FLT

72 program stepsb

  1. [18F]FDG, 2-[18F]fluoro-2-deoxy-d-glucose; d-[18F]FAC, 2-deoxy-2-[18F]fluoro-β-d-arabinofuranosyl; l-[18F]FMAU, 2-deoxy-2-[18F]flouro-5-methyl-1-β-l-arabinofuranosyl uracil; [18F]SFB, N-succinimidyl-4-[18F]fluorobenzoate; [18F]FLT, [18F]fluorothymidine; [18F]Fallypride, (S)-N-((1-allyl-2-pyrrrolidinyl)methyl)-5-(3-[18F]fluoropropyl)-2,3-dimethoxybenzamide. aThe [18F]FLT and [18F]SFB synthesis protocols for IBA Synthera® were developed at UCLA; bNumber of program steps before HPLC purification.