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Table 4 Number of operations required to synthesize common probes

From: Simplified programming and control of automated radiosynthesizers through unit operations

System Probe Operation count
ELIXYS [18F]FDG 18 unit operations
ELIXYS d-[18F]FAC 42 unit operations
ELIXYS l-[18F]FMAU 42 unit operations
ELIXYS [18F]SFB 15 unit operations
ELIXYS [18F]FLT 15 unit operations
ELIXYS [18F]Fallypride 12 unit operations
Synthera [18F]FDG 227 program steps
Synthera [18F]FLTa 241 program steps
Synthera [18F]SFBa 206 program steps
FASTlab [18F]FDG 335 program steps
Explora RN [18F]FLT 72 program stepsb
  1. [18F]FDG, 2-[18F]fluoro-2-deoxy-d-glucose; d-[18F]FAC, 2-deoxy-2-[18F]fluoro-β-d-arabinofuranosyl; l-[18F]FMAU, 2-deoxy-2-[18F]flouro-5-methyl-1-β-l-arabinofuranosyl uracil; [18F]SFB, N-succinimidyl-4-[18F]fluorobenzoate; [18F]FLT, [18F]fluorothymidine; [18F]Fallypride, (S)-N-((1-allyl-2-pyrrrolidinyl)methyl)-5-(3-[18F]fluoropropyl)-2,3-dimethoxybenzamide. aThe [18F]FLT and [18F]SFB synthesis protocols for IBA Synthera® were developed at UCLA; bNumber of program steps before HPLC purification.