Table 3 Unit operations for the synthesis of [ 18 F]FDG
From: Simplified programming and control of automated radiosynthesizers through unit operations
Unit operation | Description | |
|---|---|---|
1 | INITIALIZE | Initialize hardware |
2 | TRAPF18 | Trap [18F]fluoride for 120 s using 3 psi inert gas |
3 | ELUTEF18 | Flow eluent through elute path for 120 s using 3 psi inert gas |
4 | EVAPORATE | Evaporate reactor 1 at 110°C for 300 s using 15 psi inert gas |
5 | ELUTEF18 | Flow MeCN-1 through elute path for 90 s using 3 psi inert gas |
6 | EVAPORATE | Evaporate reactor 1 at 110°C for 120 s using 10 psi inert gas |
7 | ADD | Add MeCN-2 to reactor 1 |
8 | EVAPORATE | Evaporate reactor 1 at 110°C for 120 s using 10 psi inert gas and cool to 30°C |
9 | ADD | Add mannose triflate to reactor 1 |
10 | REACT | React reactor 1 at 130°C for 300 s and cool to 35°C with an additional 120s cooling delay |
11 | EVAPORATE | Evaporate reactor 1 at 110°C for 120 s using 10 psi inert gas |
12 | ADD | Add HCl to reactor 1 |
13 | REACT | React reactor 1 at 130°C for 300 s and cool to 35°C with an additional 120-s cooling delay |
14 | TRANSFER | Transfer the contents of reactor 1 through the purification cartridge to the collection vial. Push with 10 psi inert gas for 30 s |
15 | ADD | Add Water-1 to reactor 1 |
16 | TRANSFER | Transfer the contents of reactor 1 through the purification cartridge to the collection vial. Push with 10 psi inert gas for 30 s |
17 | ADD | Add Water-2 to reactor 1 |
18 | TRANSFER | Transfer the contents of reactor 1 through the purification cartridge to the collection vial. Push with 10 psi inert gas for 45 s |