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Table 3 Unit operations for the synthesis of [ 18 F]FDG

From: Simplified programming and control of automated radiosynthesizers through unit operations

Unit operation Description
1 INITIALIZE Initialize hardware
2 TRAPF18 Trap [18F]fluoride for 120 s using 3 psi inert gas
3 ELUTEF18 Flow eluent through elute path for 120 s using 3 psi inert gas
4 EVAPORATE Evaporate reactor 1 at 110°C for 300 s using 15 psi inert gas
5 ELUTEF18 Flow MeCN-1 through elute path for 90 s using 3 psi inert gas
6 EVAPORATE Evaporate reactor 1 at 110°C for 120 s using 10 psi inert gas
7 ADD Add MeCN-2 to reactor 1
8 EVAPORATE Evaporate reactor 1 at 110°C for 120 s using 10 psi inert gas and cool to 30°C
9 ADD Add mannose triflate to reactor 1
10 REACT React reactor 1 at 130°C for 300 s and cool to 35°C with an additional 120s cooling delay
11 EVAPORATE Evaporate reactor 1 at 110°C for 120 s using 10 psi inert gas
12 ADD Add HCl to reactor 1
13 REACT React reactor 1 at 130°C for 300 s and cool to 35°C with an additional 120-s cooling delay
14 TRANSFER Transfer the contents of reactor 1 through the purification cartridge to the collection vial. Push with 10 psi inert gas for 30 s
15 ADD Add Water-1 to reactor 1
16 TRANSFER Transfer the contents of reactor 1 through the purification cartridge to the collection vial. Push with 10 psi inert gas for 30 s
17 ADD Add Water-2 to reactor 1
18 TRANSFER Transfer the contents of reactor 1 through the purification cartridge to the collection vial. Push with 10 psi inert gas for 45 s