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Table 2 Comparison of synthesis data

From: ELIXYS - a fully automated, three-reactor high-pressure radiosynthesizer for development and routine production of diverse PET tracers

Radiotracer

Reference

Radiochemical yield (%)

Duration of synthesis (min)

Specific activity (GBq/μmol)

[18F]FAC

Amarasekera et al. [17]

39 ± 5 (n = 13)

~240

>37

This work

31 ± 5 (n = 6)

165

37 to 44

[18F]FMAU

Alauddin et al. [11]

20 to 30

210 to 240a

85.1

Mangner et al. [24]

42.1 ± 12.1 (n = 9)

160

111b

Li et al. [16]

12 ± 3 (n = 4)

150a

14.2 ± 1.2

Amarasekera et al. [17]

35 ± 6 (n = 10)

~240

>37

 

This work

46 ± 1 (n = 6)

170

100 to 170

  1. Yield, synthesis duration, and specific activity of two tracers produced with the ELIXYS radiosynthesizer compared to values found in literature. aEndpoint not specified, but presumably includes HPLC purification; btime point not specified, but presumably at time of injection.