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Table 2 Likelihood ratio test on analysis methods and model selection for MDA

From: Factors affecting tumor 18 F-FDG uptake in longitudinal mouse PET studies

Response variable

Model a

Log likelihood

Random parameters

D c

P c

AIC c

RSS

Standard b

Mixed b

K i /RC

1

45.13

48.59

a

7.16

0.0075

−90.9

1.46 × 10−4

 

2

45.79

49.32

a

7.06

0.0079

−88.64

1.31 × 10−4

 

3

31.69

31.69

a, b

2.58 × 10−5

>0.99

−56.46

0.0178

 

4

32.83

32.83

a, b

2.29 × 10−9

>0.99

−55.67

0.015

SUV/RC

1

−11.75

−9.779

A

3.95

0.047

26.48

0.591

 

2

−10.562

−6.5524

a, c

8.02

0.0456

28.73

0.129

 

3

−31.25

−31.25

a

2.54 × 10−5

>0.99

69.42

46.57

 

4

−28.28

−28.28

a

7.07 × 10−6

>0.99

66.56

32.14

  1. aModels 1 to 4 correspond to Equations 6 to 9. bStandard denotes the standard least-squares method, and mixed denotes the mixed-effects method. c D is the likelihood ratio statistic, and P is the significance level.