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Table 2 Likelihood ratio test on analysis methods and model selection for MDA

From: Factors affecting tumor 18 F-FDG uptake in longitudinal mouse PET studies

Response variable Model a Log likelihood Random parameters D c P c AIC c RSS
Standard b Mixed b
K i /RC 1 45.13 48.59 a 7.16 0.0075 −90.9 1.46 × 10−4
  2 45.79 49.32 a 7.06 0.0079 −88.64 1.31 × 10−4
  3 31.69 31.69 a, b 2.58 × 10−5 >0.99 −56.46 0.0178
  4 32.83 32.83 a, b 2.29 × 10−9 >0.99 −55.67 0.015
SUV/RC 1 −11.75 −9.779 A 3.95 0.047 26.48 0.591
  2 −10.562 −6.5524 a, c 8.02 0.0456 28.73 0.129
  3 −31.25 −31.25 a 2.54 × 10−5 >0.99 69.42 46.57
  4 −28.28 −28.28 a 7.07 × 10−6 >0.99 66.56 32.14
  1. aModels 1 to 4 correspond to Equations 6 to 9. bStandard denotes the standard least-squares method, and mixed denotes the mixed-effects method. c D is the likelihood ratio statistic, and P is the significance level.