Representative FDG Patlak Ki polar maps and linear plots. FDG Patlak Ki polar maps for TGwt baseline (A), TGwt with insulin (B), TGmut baseline (C), and TGmut following insulin (D). Representative mean derivation of Patlak analysis showing a linear plot of normalized activity vs normalized time are shown beside the polar map for each state. Solid lines represent the fit of the Patlak Ki to the linear curves at 1.58 to 7.5 min. The slope of this relationship quantifies Patlak Ki. TGwt n = 3 and TGmut n = 6.