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Table 3 Brain exposure for five different radioligands

From: 11C-LY2428703, a positron emission tomographic radioligand for the metabotropic glutamate receptor 1, is unsuitable for imaging in monkey and human brains

  11C-LY2428703 18F-FMPEP [22] 18F-SP203 [19] 11C-( R)-rolipram [23] 11C-NOP1A [24]
Target mGluR1 CB1 mGluR5 PDE4 NOP
Brain peak SUV ~0.5 3 to 4 ~6 2 to 2.5 5 to 7
Exposure SUV (0 to 20) 202.2 47.8 37.0 124.9 36.7
f p % 0.094 0.63 5.2 6.4 10.1
Effective exposure (E × f p) 0.19 0.30 1.9 8.0 3.7