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Table 1 In vitro results ( B max and K D in the cerebellar tissue and plasma free fraction) for rats, monkeys, and humans

From: 11C-LY2428703, a positron emission tomographic radioligand for the metabotropic glutamate receptor 1, is unsuitable for imaging in monkey and human brains

  B max(nM) K D(nM) B max/K D f p(%) f p× B max/K D(=V S)
Rats 167 ± 24 (3) 6.6 ± 0.3 (3) 25.3 2.7a 0.683
Monkeys 120 ± 8.6 (3) 6.6 ± 0.5 (3) 18.2 0.884 0.161
Humans 186 ± 11.6 (4)* 11.0 ± 1.6 (4) 16.9 0.094 0.016
  1. n in parentheses. *p < 0.05 monkey vs. human. aTaken from [10].