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EJNMMI Research

Table 1 In vitro results ( B max and K D in the cerebellar tissue and plasma free fraction) for rats, monkeys, and humans

From: 11C-LY2428703, a positron emission tomographic radioligand for the metabotropic glutamate receptor 1, is unsuitable for imaging in monkey and human brains

 

B max(nM)

K D(nM)

B max/K D

f p(%)

f p× B max/K D(=V S)

Rats

167 ± 24 (3)

6.6 ± 0.3 (3)

25.3

2.7a

0.683

Monkeys

120 ± 8.6 (3)

6.6 ± 0.5 (3)

18.2

0.884

0.161

Humans

186 ± 11.6 (4)*

11.0 ± 1.6 (4)

16.9

0.094

0.016

  1. n in parentheses. *p < 0.05 monkey vs. human. aTaken from [10].
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