High correlation between in vivo [123I]β-CIT SPECT/CT imaging and post-mortem immunohistochemical findings in the evaluation of lesions induced by 6-OHDA in rats

EJNMMI Research

Table 2 Correlations between different measurements

		SPECT	Rotations	TH cells	TH fibers	DAT fibers
2 weeks	SPECT	1	-0.485	0.794	0.965	0.977
	SPECT	1	P > 0.05	P < 0.005	P < 0.0001	P < 0.0001
	Rotations	-	1	0.089	0.462	0.499
	Rotations	-	1	P > 0.05	P > 0.05	P > 0.05
	TH cells	-	-	1	0.724	0.752
	TH cells	-	-	1	P < 0.01	P < 0.005
	TH fibers	-	-	-	1	0.981
	TH fibers	-	-	-	1	P < 0.0001
	DAT fibers	-	-	-	-	1
4 weeks	SPECT	1	-0.538	0.838	0.911	0.936
	SPECT	1	P < 0.05	P < 0.0001	P < 0.0001	P < 0.0001
	Rotations	-	1	0.754	0.656	0.630
	Rotations	-	1	P < 0.005	P < 0.05	P < 0.05
	TH cells	-	-	1	0.731	0.769
	TH cells	-	-	1	P < 0.005	P < 0.005
	TH fibers	-	-	-	1	0.985
	TH fibers	-	-	-	1	P < 0.0001
	DAT fibers	-	-	-	-	1

Correlation coefficients (italic numbers) and statistical significance (P) were determined with Pearson correlation (n = 12 to 13 at 2 weeks post-lesion, and n = 14 at 4 weeks post-lesion).