Skip to main content

Table 1 Quantitative results from [ 123 I]β-CIT SPECT/CT and TH-reactive cell counts

From: High correlation between in vivo [123I]β-CIT SPECT/CT imaging and post-mortem immunohistochemical findings in the evaluation of lesions induced by 6-OHDA in rats

 

Intact

8 μg 6-OHDA

2 × 10 μg 6-OHDA

 

Left

Right

Left

Right

Left

Right

Mean striatal uptake of [123I]β-CIT (×10-4 MBq/mm3)

2 weeks

2.3 ± 0.3

2.1 ± 0.3

2.0 ± 0.2*

2.6 ± 0.3

1.4 ± 0.2**

2.2 ± 0.2

4 weeks

1.7 ± 0.1**

2.2 ± 0.1

1.4 ± 0.1**

2.3 ± 0.2

TH-reactive cells in the SNpc

2 weeks

8,047 ± 1,074

8,675 ± 487

5,426 ± 586*

8,232 ± 164

2,894 ± 312**

8,328 ± 439

 

4 weeks

  

5,759 ± 640*

8,298 ± 338

2,658 ± 655**

8,239 ± 434

  1. Striatal [123I]β-CIT binding detected with SPECT/CT and TH-reactive cell numbers in the SNpc at 2 and 4 weeks after induction of 6-OHDA-mediated degeneration of the rat midbrain dopaminergic pathway. Unilateral injection of 6-OHDA (8 or 2 × 10 μg) to the left rat striatum resulted in a significant decrease in striatal [123I]β-CIT uptake and nigral TH-reactive cell counts when compared to the right (intact) side. The results are given as mean ± SEM. *P < 0.05 and **P < 0.01 as compared to the right (intact) side (paired samples t test, n = 4 to 5 per group).
Back to article page