Pilot study of PET imaging of 124I-iodoazomycin galactopyranoside (IAZGP), a putative hypoxia imaging agent, in patients with colorectal cancer and head and neck cancer

O’Donoghue, Joseph A; Guillem, José G; Schöder, Heiko; Lee, Nancy Y; Divgi, Chaitanya R; Ruby, Jeannine A; Humm, John L; Lee-Kong, Steven A; Burnazi, Eva M; Cai, Shangde; Carlin, Sean D; Leibold, Tobias; Zanzonico, Pat B; Ling, C Clifton

doi:10.1186/2191-219X-3-42

EJNMMI Research

Table 4 Estimated absorbed dose to normal tissues for ¹²⁴ I-IAZGP

From: Pilot study of PET imaging of ¹²⁴I-iodoazomycin galactopyranoside (IAZGP), a putative hypoxia imaging agent, in patients with colorectal cancer and head and neck cancer

	Patient number										Mean	SD
	1	2	3	4	5	6	7	8	9	10	Mean	SD
Sex	M	M	M	M	M	M	M	M	F	F
Adrenals	0.038	0.043	0.034	0.022	0.027	0.024	0.021	0.039	0.034	0.022	0.030	0.008
Brain	0.025	0.025	0.019	0.013	0.017	0.016	0.015	0.026	0.021	0.015	0.019	0.005
Breasts	0.024	0.025	0.020	0.013	0.017	0.015	0.015	0.025	0.021	0.014	0.019	0.005
Gallbladder wall	0.046	0.053	0.045	0.035	0.036	0.033	0.026	0.054	0.047	0.026	0.040	0.011
LLI wall	0.33	0.32	0.29	0.49	0.35	0.34	0.16	0.52	0.52	0.14	0.35	0.13
Small intestine	0.080	0.080	0.068	0.090	0.074	0.071	0.043	0.108	0.110	0.042	0.077	0.023
Stomach wall	0.039	0.041	0.033	0.027	0.029	0.027	0.023	0.043	0.038	0.022	0.032	0.008
ULI wall	0.16	0.16	0.14	0.23	0.17	0.16	0.08	0.25	0.25	0.07	0.17	0.06
Heart wall	0.043	0.057	0.036	0.024	0.036	0.022	0.020	0.045	0.037	0.025	0.035	0.012
Kidneys	0.083	0.112	0.079	0.036	0.037	0.051	0.021	0.053	0.055	0.035	0.056	0.028
Liver	0.044	0.081	0.074	0.034	0.033	0.027	0.021	0.055	0.043	0.030	0.044	0.020
Lungs	0.028	0.042	0.029	0.019	0.021	0.018	0.018	0.035	0.027	0.019	0.025	0.008
Muscle	0.035	0.035	0.029	0.024	0.027	0.025	0.022	0.038	0.033	0.022	0.029	0.006
Pancreas	0.040	0.044	0.035	0.024	0.029	0.026	0.023	0.043	0.036	0.023	0.032	0.008
Red marrow	0.041	0.049	0.034	0.029	0.035	0.026	0.020	0.046	0.042	0.025	0.035	0.010
Osteogenic cells	0.049	0.053	0.039	0.029	0.037	0.030	0.027	0.052	0.048	0.031	0.039	0.010
Skin	0.024	0.025	0.020	0.015	0.018	0.016	0.015	0.026	0.022	0.015	0.019	0.004
Spleen	0.035	0.055	0.053	0.026	0.025	0.025	0.020	0.035	0.032	0.022	0.033	0.012
Testes	0.039	0.039	0.033	0.029	0.031	0.031	0.027	0.042	-	-	0.034	0.005
Thymus	0.030	0.033	0.024	0.016	0.022	0.018	0.018	0.032	0.026	0.018	0.024	0.006
Thyroid	0.025	0.044	0.022	0.016	0.019	0.016	0.018	0.027	0.021	0.014	0.022	0.009
Total body	0.037	0.039	0.031	0.026	0.028	0.026	0.022	0.041	0.036	0.023	0.031	0.007
UB wall (1 h)	0.25	0.25	0.25	0.26	0.25	0.27	0.24	0.26	0.35	0.35	0.27	0.04
UB wall (2.5 h)	0.58	0.58	0.61	0.69	0.61	0.71	0.61	0.61	0.88	0.95	0.68	0.13
Effective dose (mSv/MBq)	0.097	0.10	0.089	0.11	0.094	0.093	0.061	0.13	0.13	0.072	0.098	0.023

All absorbed dose values are expressed in mGy/MBq. Effective dose is expressed in mSv/MBq [32]. Urinary bladder (UB) wall (t) denotes absorbed dose to the bladder wall for a voiding interval of t.

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