Compound |
K
i(nM)
a
| Log D | cPSA
d(Å
2) |
---|
| hCA I
b
| hCA II
b
| | |
---|
(3) | 96 | 8 | 1.13 | 99 |
(4) | 390 | 20 | 1.19 | 99 |
(5) | 30,850 | 336 | 0.32 | 69 |
(6) | 24,700 | 422 | 0.42 | 69 |
AAZ | 250 | 12 | −1.5c
| 109 |
- For CO2 hydration reaction at 20°C. aStandard errors of the mean in the range of 5% to 10% of the reported value (n = 3, different assays); bhuman (cloned) isozymes; ccLog D; dcPSA = (calculated) polar surface area.