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Table 1 K i of reference compounds (3 to 6) against carbonic anhydrase isozymes hCA I and II

From: Preclinical evaluation of carbon-11 and fluorine-18 sulfonamide derivatives for in vivo radiolabeling of erythrocytes

Compound K i(nM) a Log D cPSA d2)
  hCA I b hCA II b   
(3) 96 8 1.13 99
(4) 390 20 1.19 99
(5) 30,850 336 0.32 69
(6) 24,700 422 0.42 69
AAZ 250 12 −1.5c 109
  1. For CO2 hydration reaction at 20°C. aStandard errors of the mean in the range of 5% to 10% of the reported value (n = 3, different assays); bhuman (cloned) isozymes; ccLog D; dcPSA = (calculated) polar surface area.