Skip to main content

Table 1 K i of reference compounds (3 to 6) against carbonic anhydrase isozymes hCA I and II

From: Preclinical evaluation of carbon-11 and fluorine-18 sulfonamide derivatives for in vivo radiolabeling of erythrocytes

Compound

K i(nM) a

Log D

cPSA d2)

 

hCA I b

hCA II b

  

(3)

96

8

1.13

99

(4)

390

20

1.19

99

(5)

30,850

336

0.32

69

(6)

24,700

422

0.42

69

AAZ

250

12

−1.5c

109

  1. For CO2 hydration reaction at 20°C. aStandard errors of the mean in the range of 5% to 10% of the reported value (n = 3, different assays); bhuman (cloned) isozymes; ccLog D; dcPSA = (calculated) polar surface area.