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Table 1 Biodistribution of 68 Ga-NODAGA-RGD and 68 Ga-TRAP(RGD) 3 in tissues 90 min p.i

From: Comparison of cyclic RGD peptides for αvβ3 integrin detection in a rat model of myocardial infarction

 

68Ga-NODAGA-RGD

68Ga-TRAP(RGD) 3

 

Mean ± SD

Mean ± SD

n= 9

n= 10

p Value

Blood

0.058 ± 0.02

0.101 ± 0.07

ns

Serum

0.094 ± 0.05

0.166 ± 0.12

ns

Remote myocardium

0.071 ± 0.03

0.154 ± 0.09

0.02

Apical myocardium

0.156 ± 0.06

0.353 ± 0.10

-

Muscle

0.035 ± 0.01

0.066 ± 0.03

0.028

Connective tissue

0.110 ± 0.05

0.190 ± 0.08

0.031

Wound

0.270 ± 0.24

0.256 ± 0.12

ns

Spleen

0.246 ± 0.16

0.415 ± 0.30

ns

Liver

0.230 ± 0.17

0.524 ± 0.61

ns

Kidney

1.102 ± 0.70

1.447 ± 0.51

ns

Urine

20.24 ± 6.40

35.10 ± 22.37

ns

  1. Ns, not significant; p.i., post-injection. Results presented as percentage of injected dose per gram of tissue (% ID/g). The apical myocardium contains both infarct and remote areas, as can be seen in processed transaxial sections for autoradiography.