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Table 2 Human absorbed dose (mGy/MBq) and effective dose (mSv/MBq)

From: Preclinical radiation dosimetry for the novel SV2A radiotracer [18F]UCB-H

Target Organ TD %CV TD NE Dynamic single %CV Dynamic single NE
Adrenals 1.43E-02 1.7 1.65E-02 1.36E-02 1.0 1.44E-02
Brain 3.08E-02 16.7 2.05E-02 8.61E-03 1.1 8.27E-03
Breasts 7.71E-03 2.9 7.18E-03 8.88E-03 0.7 8.36E-03
Gallbladder wall 1.86E-02 4.3 2.26E-02 1.56E-02 1.7 1.75E-02
LLI wall 1.36E-02 4.0 1.28E-02 1.55E-02 0.8 1.52E-02
Small intestine 1.24E-02 3.2 1.22E-02 1.37E-02 0.5 1.37E-02
Stomach wall 1.11E-02 2.3 1.11E-02 1.20E-02 0.4 1.20E-02
ULI wall 1.25E-02 2.4 1.27E-02 1.34E-02 0.6 1.36E-02
Heart wall 1.76E-02 6.5 1.77E-02 2.09E-02 9.2 1.26E-02
Kidneys 2.96E-02 8.4 7.07E-02 1.87E-02 9.1 4.06E-02
Liver 5.84E-02 12.6 8.40E-02 3.14E-02 6.3 4.32E-02
Lungs 1.64E-02 6.7 1.11E-02 2.17E-02 12.0 1.23E-02
Muscle 9.82E-03 3.1 9.42E-03 1.10E-02 0.4 1.08E-02
Ovaries 1.38E-02 4.0 1.30E-02 1.57E-02 0.7 1.54E-02
Pancreas 1.40E-02 0.7 1.55E-02 1.37E-02 0.7 1.43E-02
Red marrow 9.71E-03 2.0 9.41E-03 1.04E-02 0.4 1.03E-02
Osteogenic cells 1.39E-02 3.6 1.26E-02 1.57E-02 0.8 1.53E-02
Skin 7.22E-03 3.7 6.73E-03 8.17E-03 0.7 8.00E-03
Spleen 1.52E-02 7.9 1.50E-02 1.15E-02 0.5 1.16E-02
Testes 1.58E-02 6.6 1.13E-01 1.25E-02 5.1 6.41E-02
Thymus 9.26E-03 3.5 8.39E-03 1.09E-02 0.8 1.01E-02
Thyroid 8.86E-03 4.1 7.62E-03 1.01E-02 0.9 9.63E-03
Urinary bladder wall 1.54E-01 0.3 1.54E-01 1.56E-01 0.0 1.56E-01
Uterus 1.90E-02 2.9 1.82E-02 2.09E-02 0.5 2.06E-02
Total body 1.19E-02 0.0 1.21E-02 1.18E-02 0.4 1.19E-02
Effective dose (mSv/MBq) 1.88E-02 2.7 2.72E-02 1.84E-02 1.9 2.19E-02
  1. Human absorbed dose (mGy/MBq) and effective dose for ICRP 103 weighting factors (mSv/MBq) derived by animal tissue distribution (TD) and dynamic imaging based on single sphere segmentation (both bladder fraction 0.5) for the standard 70-kg male phantom including no extrapolation (NE) estimation based on pure animal data.