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Table 2 Human absorbed dose (mGy/MBq) and effective dose (mSv/MBq)

From: Preclinical radiation dosimetry for the novel SV2A radiotracer [18F]UCB-H

Target Organ

TD

%CV

TD NE

Dynamic single

%CV

Dynamic single NE

Adrenals

1.43E-02

1.7

1.65E-02

1.36E-02

1.0

1.44E-02

Brain

3.08E-02

16.7

2.05E-02

8.61E-03

1.1

8.27E-03

Breasts

7.71E-03

2.9

7.18E-03

8.88E-03

0.7

8.36E-03

Gallbladder wall

1.86E-02

4.3

2.26E-02

1.56E-02

1.7

1.75E-02

LLI wall

1.36E-02

4.0

1.28E-02

1.55E-02

0.8

1.52E-02

Small intestine

1.24E-02

3.2

1.22E-02

1.37E-02

0.5

1.37E-02

Stomach wall

1.11E-02

2.3

1.11E-02

1.20E-02

0.4

1.20E-02

ULI wall

1.25E-02

2.4

1.27E-02

1.34E-02

0.6

1.36E-02

Heart wall

1.76E-02

6.5

1.77E-02

2.09E-02

9.2

1.26E-02

Kidneys

2.96E-02

8.4

7.07E-02

1.87E-02

9.1

4.06E-02

Liver

5.84E-02

12.6

8.40E-02

3.14E-02

6.3

4.32E-02

Lungs

1.64E-02

6.7

1.11E-02

2.17E-02

12.0

1.23E-02

Muscle

9.82E-03

3.1

9.42E-03

1.10E-02

0.4

1.08E-02

Ovaries

1.38E-02

4.0

1.30E-02

1.57E-02

0.7

1.54E-02

Pancreas

1.40E-02

0.7

1.55E-02

1.37E-02

0.7

1.43E-02

Red marrow

9.71E-03

2.0

9.41E-03

1.04E-02

0.4

1.03E-02

Osteogenic cells

1.39E-02

3.6

1.26E-02

1.57E-02

0.8

1.53E-02

Skin

7.22E-03

3.7

6.73E-03

8.17E-03

0.7

8.00E-03

Spleen

1.52E-02

7.9

1.50E-02

1.15E-02

0.5

1.16E-02

Testes

1.58E-02

6.6

1.13E-01

1.25E-02

5.1

6.41E-02

Thymus

9.26E-03

3.5

8.39E-03

1.09E-02

0.8

1.01E-02

Thyroid

8.86E-03

4.1

7.62E-03

1.01E-02

0.9

9.63E-03

Urinary bladder wall

1.54E-01

0.3

1.54E-01

1.56E-01

0.0

1.56E-01

Uterus

1.90E-02

2.9

1.82E-02

2.09E-02

0.5

2.06E-02

Total body

1.19E-02

0.0

1.21E-02

1.18E-02

0.4

1.19E-02

Effective dose (mSv/MBq)

1.88E-02

2.7

2.72E-02

1.84E-02

1.9

2.19E-02

  1. Human absorbed dose (mGy/MBq) and effective dose for ICRP 103 weighting factors (mSv/MBq) derived by animal tissue distribution (TD) and dynamic imaging based on single sphere segmentation (both bladder fraction 0.5) for the standard 70-kg male phantom including no extrapolation (NE) estimation based on pure animal data.