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EJNMMI Research

Table 3 Absorbed doses in the source organs

From: Evaluation of the biodistribution and radiation dosimetry of the 18F-labelled amyloid imaging probe [18F]FACT in humans

 

Human

Mouse

 

All subjects (n= 6)

Male

Female

 
  

(n= 3)

(n= 3)

 

Organ

    

Adrenal gland

1.96E01 ± 2.00

2.03E01

1.90E01

1.35E01

Brain

9.91 ± 1.82

8.95

1.09E01

4.17

Breasts

8.69 ± 2.55

6.68

1.07E01

9.90

Gallbladder wall

3.33E02 ± 2.51E02

2.16E02

4.50E02

1.68E01

Lower large intestine wall

2.52E01 ± 1.26E01

2.41E01

2.63E01

1.57E01

Small intestine

3.36E01 ± 3.07E01

2.07E01

4.64.E01

3.85E01

Stomach wall

1.61E01 ± 3.44

1.35E01

1.87E01

1.39E01

Upper large intestine wall

2.98E01 ± 1.50E01

2.36E01

3.59E01

1.83E01

Heart wall

1.62E01 ± 1.70

1.50E01

1.74E01

8.34

Kidneys

2.01E01 ± 4.30

1.85E01

2.17E01

1.32E01

Liver

7.75E01 ± 1.45E01

7.38E01

8.11E01

2.55E01

Lungs

1.46E01 ± 1.10

1.49E01

1.43E01

7.96

Muscle

1.03E01 ± 1.27

1.07E01

9.90

7.89

Ovary

1.67E01 ± 6.65

1.18E01

2.16E01

1.67E01

Pancreas

2.32E01 ± 3.11

2.17E01

2.47E01

1.45E01

Red marrow

1.31E01 ± 1.70

1.16E01

1.46E01

1.23E01

Osteogenic cells

1.60E01 ± 3.65

1.25E01

1.95E01

1.82E01

Skin

7.30 ± 1.39

5.99

8.60

8.70

Spleen

1.37E01 ± 2.48

1.27E01

1.48E01

7.83

Testis

7.32 ± 2.16

7.32

-

1.15E01

Thymus

1.00E01 ± 1.85

8.37

1.16E01

1.08E01

Thyroid

8.36 ± 1.38

8.86

7.86

1.10E01

Urinary bladder wall

2.23E01 ± 7.33

1.81E01

2.66E01

4.31E01

Uterus

1.67E01 ± 8.13

1.14E01

2.19E01

1.77E01

Total body

1.38E01 ± 1.63

1.22E01

1.53E01

1.22E01

Effective dose (μSv/MBq)

1.86E01 ± 3.74

1.64E01

2.09E01

1.48E01

  1. Averaged absorbed dose estimates (μGy/MBq) for the target organs from the whole-body PET data (n = 6) from experiments involving human subjects of [18F]FACT and mice of [18F]FACT. Average absorbed dose for male subjects (n = 3).
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