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EJNMMI Research

Table 2 [ 18 F]FACT time-integrated activity coefficients in the source organs

From: Evaluation of the biodistribution and radiation dosimetry of the 18F-labelled amyloid imaging probe [18F]FACT in humans

Organ

Human (MBq-h/MBq)

Mouse (MBq-h/MBq)

 

Mean ± 1 SD

Subject 1

Subject 2

Subject 3

Subject 4

Subject 5

Subject 6

 

Adrenal gland

5.38E−04 ± 2.98E−04

9.40E−04

8.40E−04

5.20E−04

3.70E−04

4.00E−04

1.60E−04

-

Brain

4.20E−02 ± 8.44E−03

5.41E−02

3.68E−02

3.53E−02

4.87E−02

4.42E−02

3.26E−02

6.99E−03

Breast

8.40E−03 ± 4.37E−03

1.14E−03

8.25E−03

5.59E−03

1.16E−02

1.19E−02

1.19E−02

-

Gallbladder contenta

2.22E−01 ± 1.05E−01

-

1.49E−01

2.27E−01

3.88E−01

1.16E−01

2.31E−01

-

Lower large intestine content

2.12E−02 ± 2.03E−02

5.91E−02

1.06E−02

4.80E−03

2.27E−02

2.40E−02

5.96E−03

-

Small intestine content

8.78E−02 ± 1.08E−01

7.40E−02

3.74E−02

3.34E−02

3.06E−01

3.36E−02

4.25E−02

1.22E−01

Stomach content

6.71E−03 ± 2.28E−03

5.22E−03

6.23E−03

9.29E−03

9.84E−03

4.78E−03

4.87E−03

-

Upper large intestine content

2.55E−02 ± 1.89E−02

1.48E−02

4.88E−02

1.01E−02

4.99E−02

2.04E−02

8.85E−03

-

Heart content

1.12.E−02 ± 1.51E−03

1.24E−02

1.13E−02

1.02E−02

1.30E−02

1.15E−02

8.83E−03

3.95E−03

Heart wall

7.50E−03 ± 1.84E−03

4.63E−03

1.00E−02

8.84E−03

6.75E−03

7.28E−03

7.49E−03

2.39E−03

Kidney

1.34E−02 ± 3.27E−03

1.32E−02

1.16E−02

1.53E−02

1.89E−02

9.59E−03

1.20E−02

9.34E−03

Liver

4.92E−01 ± 1.05E−01

6.28E−01

5.85E−01

4.34E−01

5.15E−01

3.42E−01

4.49E−01

1.69E−01

Lung

3.55E−02 ± 1.16E−02

3.78E−02

5.31E−02

4.36E−02

2.46E−02

2.33E−02

3.08E−02

1.17E−02

Muscle

4.66E−01 ± 3.73E−01

9.43E−01

5.47E−01

7.97E−01

5.40E−02

4.12E−01

4.34E−02

1.57E−01

Ovaryb

5.53E−04 ± 3.79E−05

-

-

-

5.70E−04

5.10E−04

5.80E−04

-

Pancreas

4.13E−03 ± 9.75E−04

6.10E−03

3.62E−03

3.93E−03

3.81E−03

3.55E−03

3.76E−03

-

Red marrow

3.98E−02 ± 4.33E−03

4.02E−02

3.83E−02

3.79E−02

4.59E−02

4.29E−02

3.34E−02

1.61E−02

Spleen

5.41E−03 ± 1.74E−03

8.64E−03

4.88E−03

3.83E−03

6.01E−03

4.77E−03

4.30E−03

1.28E−03

Testisc

5.77E−04 ± 4.67E−04

7.00E−04

6.10E−05

9.70E−04

-

-

-

-

Thyroid

3.53E−04 ± 1.55E−04

6.30E−04

3.70E−04

3.60E−04

2.40E−04

1.80E−04

3.40E−04

-

Urinary bladder contents

2.26E−02 ± 8.36E−03

1.70E−02

2.69E−02

1.55E−02

3.63E−02

2.49E−02

1.51E−02

6.56E−02

Uterus/uterine wallb

4.46E−03 ± 1.90E−03

-

-

-

6.42E−03

2.63E−03

4.33E−03

-

Remainder of the body

1.17 ± 3.63E−01

7.24E−01

1.06

9.48E−01

1.08

1.51

1.69

2.08

  1. Averaged time-integrated activity coefficient (MBq-h/MBq) for the source organs (n = 6) from the whole-body PET data (n = 6) from experiments involving human subjects of [18F]FACT and mice of [18F]FACT. aAveraged value among five subjects excluding subject no. 1. bAverage time-integrated activity coefficient among female subjects (n = 3). cAverage time-integrated activity coefficient among male subjects (n = 3).
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