|
Organ
|
Human (MBq-h/MBq)
|
Mouse (MBq-h/MBq)
|
|---|
| |
Mean ± 1 SD
|
Subject 1
|
Subject 2
|
Subject 3
|
Subject 4
|
Subject 5
|
Subject 6
| |
|---|
|
Adrenal gland
|
5.38E−04 ± 2.98E−04
|
9.40E−04
|
8.40E−04
|
5.20E−04
|
3.70E−04
|
4.00E−04
|
1.60E−04
|
-
|
|
Brain
|
4.20E−02 ± 8.44E−03
|
5.41E−02
|
3.68E−02
|
3.53E−02
|
4.87E−02
|
4.42E−02
|
3.26E−02
|
6.99E−03
|
|
Breast
|
8.40E−03 ± 4.37E−03
|
1.14E−03
|
8.25E−03
|
5.59E−03
|
1.16E−02
|
1.19E−02
|
1.19E−02
|
-
|
|
Gallbladder contenta
|
2.22E−01 ± 1.05E−01
|
-
|
1.49E−01
|
2.27E−01
|
3.88E−01
|
1.16E−01
|
2.31E−01
|
-
|
|
Lower large intestine content
|
2.12E−02 ± 2.03E−02
|
5.91E−02
|
1.06E−02
|
4.80E−03
|
2.27E−02
|
2.40E−02
|
5.96E−03
|
-
|
|
Small intestine content
|
8.78E−02 ± 1.08E−01
|
7.40E−02
|
3.74E−02
|
3.34E−02
|
3.06E−01
|
3.36E−02
|
4.25E−02
|
1.22E−01
|
|
Stomach content
|
6.71E−03 ± 2.28E−03
|
5.22E−03
|
6.23E−03
|
9.29E−03
|
9.84E−03
|
4.78E−03
|
4.87E−03
|
-
|
|
Upper large intestine content
|
2.55E−02 ± 1.89E−02
|
1.48E−02
|
4.88E−02
|
1.01E−02
|
4.99E−02
|
2.04E−02
|
8.85E−03
|
-
|
|
Heart content
|
1.12.E−02 ± 1.51E−03
|
1.24E−02
|
1.13E−02
|
1.02E−02
|
1.30E−02
|
1.15E−02
|
8.83E−03
|
3.95E−03
|
|
Heart wall
|
7.50E−03 ± 1.84E−03
|
4.63E−03
|
1.00E−02
|
8.84E−03
|
6.75E−03
|
7.28E−03
|
7.49E−03
|
2.39E−03
|
|
Kidney
|
1.34E−02 ± 3.27E−03
|
1.32E−02
|
1.16E−02
|
1.53E−02
|
1.89E−02
|
9.59E−03
|
1.20E−02
|
9.34E−03
|
|
Liver
|
4.92E−01 ± 1.05E−01
|
6.28E−01
|
5.85E−01
|
4.34E−01
|
5.15E−01
|
3.42E−01
|
4.49E−01
|
1.69E−01
|
|
Lung
|
3.55E−02 ± 1.16E−02
|
3.78E−02
|
5.31E−02
|
4.36E−02
|
2.46E−02
|
2.33E−02
|
3.08E−02
|
1.17E−02
|
|
Muscle
|
4.66E−01 ± 3.73E−01
|
9.43E−01
|
5.47E−01
|
7.97E−01
|
5.40E−02
|
4.12E−01
|
4.34E−02
|
1.57E−01
|
|
Ovaryb
|
5.53E−04 ± 3.79E−05
|
-
|
-
|
-
|
5.70E−04
|
5.10E−04
|
5.80E−04
|
-
|
|
Pancreas
|
4.13E−03 ± 9.75E−04
|
6.10E−03
|
3.62E−03
|
3.93E−03
|
3.81E−03
|
3.55E−03
|
3.76E−03
|
-
|
|
Red marrow
|
3.98E−02 ± 4.33E−03
|
4.02E−02
|
3.83E−02
|
3.79E−02
|
4.59E−02
|
4.29E−02
|
3.34E−02
|
1.61E−02
|
|
Spleen
|
5.41E−03 ± 1.74E−03
|
8.64E−03
|
4.88E−03
|
3.83E−03
|
6.01E−03
|
4.77E−03
|
4.30E−03
|
1.28E−03
|
|
Testisc
|
5.77E−04 ± 4.67E−04
|
7.00E−04
|
6.10E−05
|
9.70E−04
|
-
|
-
|
-
|
-
|
|
Thyroid
|
3.53E−04 ± 1.55E−04
|
6.30E−04
|
3.70E−04
|
3.60E−04
|
2.40E−04
|
1.80E−04
|
3.40E−04
|
-
|
|
Urinary bladder contents
|
2.26E−02 ± 8.36E−03
|
1.70E−02
|
2.69E−02
|
1.55E−02
|
3.63E−02
|
2.49E−02
|
1.51E−02
|
6.56E−02
|
|
Uterus/uterine wallb
|
4.46E−03 ± 1.90E−03
|
-
|
-
|
-
|
6.42E−03
|
2.63E−03
|
4.33E−03
|
-
|
|
Remainder of the body
|
1.17 ± 3.63E−01
|
7.24E−01
|
1.06
|
9.48E−01
|
1.08
|
1.51
|
1.69
|
2.08
|
- Averaged time-integrated activity coefficient (MBq-h/MBq) for the source organs (n = 6) from the whole-body PET data (n = 6) from experiments involving human subjects of [18F]FACT and mice of [18F]FACT. aAveraged value among five subjects excluding subject no. 1. bAverage time-integrated activity coefficient among female subjects (n = 3). cAverage time-integrated activity coefficient among male subjects (n = 3).
