Evaluation of the biodistribution and radiation dosimetry of the 18 F-labelled amyloid imaging probe [ 18 F]FACT in humans

Miho Shidahara; Manabu Tashiro; Nobuyuki Okamura; Shozo Furumoto; Katsutoshi Furukawa; Shoichi Watanuki; Kotaro Hiraoka; Masayasu Miyake; Ren Iwata; Hajime Tamura; Hiroyuki Arai; Yukitsuka Kudo; Kazuhiko Yanai

doi:10.1186/2191-219X-3-32

EJNMMI Research

Table 2 [ ¹⁸ F]FACT time-integrated activity coefficients in the source organs

From: Evaluation of the biodistribution and radiation dosimetry of the ¹⁸F-labelled amyloid imaging probe [¹⁸F]FACT in humans

Organ	Human (MBq-h/MBq)							Mouse (MBq-h/MBq)
	Mean ± 1 SD	Subject 1	Subject 2	Subject 3	Subject 4	Subject 5	Subject 6
Adrenal gland	5.38E−04 ± 2.98E−04	9.40E−04	8.40E−04	5.20E−04	3.70E−04	4.00E−04	1.60E−04	-
Brain	4.20E−02 ± 8.44E−03	5.41E−02	3.68E−02	3.53E−02	4.87E−02	4.42E−02	3.26E−02	6.99E−03
Breast	8.40E−03 ± 4.37E−03	1.14E−03	8.25E−03	5.59E−03	1.16E−02	1.19E−02	1.19E−02	-
Gallbladder content^a	2.22E−01 ± 1.05E−01	-	1.49E−01	2.27E−01	3.88E−01	1.16E−01	2.31E−01	-
Lower large intestine content	2.12E−02 ± 2.03E−02	5.91E−02	1.06E−02	4.80E−03	2.27E−02	2.40E−02	5.96E−03	-
Small intestine content	8.78E−02 ± 1.08E−01	7.40E−02	3.74E−02	3.34E−02	3.06E−01	3.36E−02	4.25E−02	1.22E−01
Stomach content	6.71E−03 ± 2.28E−03	5.22E−03	6.23E−03	9.29E−03	9.84E−03	4.78E−03	4.87E−03	-
Upper large intestine content	2.55E−02 ± 1.89E−02	1.48E−02	4.88E−02	1.01E−02	4.99E−02	2.04E−02	8.85E−03	-
Heart content	1.12.E−02 ± 1.51E−03	1.24E−02	1.13E−02	1.02E−02	1.30E−02	1.15E−02	8.83E−03	3.95E−03
Heart wall	7.50E−03 ± 1.84E−03	4.63E−03	1.00E−02	8.84E−03	6.75E−03	7.28E−03	7.49E−03	2.39E−03
Kidney	1.34E−02 ± 3.27E−03	1.32E−02	1.16E−02	1.53E−02	1.89E−02	9.59E−03	1.20E−02	9.34E−03
Liver	4.92E−01 ± 1.05E−01	6.28E−01	5.85E−01	4.34E−01	5.15E−01	3.42E−01	4.49E−01	1.69E−01
Lung	3.55E−02 ± 1.16E−02	3.78E−02	5.31E−02	4.36E−02	2.46E−02	2.33E−02	3.08E−02	1.17E−02
Muscle	4.66E−01 ± 3.73E−01	9.43E−01	5.47E−01	7.97E−01	5.40E−02	4.12E−01	4.34E−02	1.57E−01
Ovary^b	5.53E−04 ± 3.79E−05	-	-	-	5.70E−04	5.10E−04	5.80E−04	-
Pancreas	4.13E−03 ± 9.75E−04	6.10E−03	3.62E−03	3.93E−03	3.81E−03	3.55E−03	3.76E−03	-
Red marrow	3.98E−02 ± 4.33E−03	4.02E−02	3.83E−02	3.79E−02	4.59E−02	4.29E−02	3.34E−02	1.61E−02
Spleen	5.41E−03 ± 1.74E−03	8.64E−03	4.88E−03	3.83E−03	6.01E−03	4.77E−03	4.30E−03	1.28E−03
Testis^c	5.77E−04 ± 4.67E−04	7.00E−04	6.10E−05	9.70E−04	-	-	-	-
Thyroid	3.53E−04 ± 1.55E−04	6.30E−04	3.70E−04	3.60E−04	2.40E−04	1.80E−04	3.40E−04	-
Urinary bladder contents	2.26E−02 ± 8.36E−03	1.70E−02	2.69E−02	1.55E−02	3.63E−02	2.49E−02	1.51E−02	6.56E−02
Uterus/uterine wall^b	4.46E−03 ± 1.90E−03	-	-	-	6.42E−03	2.63E−03	4.33E−03	-
Remainder of the body	1.17 ± 3.63E−01	7.24E−01	1.06	9.48E−01	1.08	1.51	1.69	2.08

Averaged time-integrated activity coefficient (MBq-h/MBq) for the source organs (n = 6) from the whole-body PET data (n = 6) from experiments involving human subjects of [¹⁸F]FACT and mice of [¹⁸F]FACT. ^aAveraged value among five subjects excluding subject no. 1. ^bAverage time-integrated activity coefficient among female subjects (n = 3). ^cAverage time-integrated activity coefficient among male subjects (n = 3).

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