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Table 2 Specific radioactivity (decay-corrected) of PET radiotracers measured by LC-MS/MS and radiometric methods

From: Characterization of fast-decaying PET radiotracers solely through LC-MS/MS of constituent radioactive and carrier isotopologues

Radiotracer

SA (GBq/μmol)

Difference b(%)

LC-MS/MS a

Radiometry

[11C]PBR28

265.5 ± 8.5

290.8

−9.1

330.4 ± 5.8

363.6

−9.6

167.0 ± 2.9

173.3

−3.7

[11C]dLop

234.1 ± 3.2

237.9

−1.6

227.1 ± 6.1

253.2

−10.9

241.4 ± 7.0

264.0

−9.1

[11C]MePPEP

160.1 ± 7.2

151.5

+5.5

244.0 ± 11.7

238.0

+2.5

82.5 ± 3.0

92.4

−11.3

[11C](R)-Rolipram

473.9 ± 4.8

459.9

+3.0

505.0 ± 9.5

450.5

+11.4

459.0 ± 5.8

411.1

+11.0

  1. aMean ± SD specific radioactivity from six consecutive analyses; bDifference (%) = [(LC-MS/MS − radiometry) / mean of both methods] × 100.