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Table 2 Specific radioactivity (decay-corrected) of PET radiotracers measured by LC-MS/MS and radiometric methods

From: Characterization of fast-decaying PET radiotracers solely through LC-MS/MS of constituent radioactive and carrier isotopologues

Radiotracer SA (GBq/μmol) Difference b(%)
LC-MS/MS a Radiometry
[11C]PBR28 265.5 ± 8.5 290.8 −9.1
330.4 ± 5.8 363.6 −9.6
167.0 ± 2.9 173.3 −3.7
[11C]dLop 234.1 ± 3.2 237.9 −1.6
227.1 ± 6.1 253.2 −10.9
241.4 ± 7.0 264.0 −9.1
[11C]MePPEP 160.1 ± 7.2 151.5 +5.5
244.0 ± 11.7 238.0 +2.5
82.5 ± 3.0 92.4 −11.3
[11C](R)-Rolipram 473.9 ± 4.8 459.9 +3.0
505.0 ± 9.5 450.5 +11.4
459.0 ± 5.8 411.1 +11.0
  1. aMean ± SD specific radioactivity from six consecutive analyses; bDifference (%) = [(LC-MS/MS − radiometry) / mean of both methods] × 100.