Quantitative lung SPECT applied on simulated early COPD and humans with advanced COPD

Table 2 Subjects’ gender, age, FEV ₁ , FEV ₁ /VC and AUC(CV _T )

Subject	Label	Gender	Age (years)	FEV ₁(% predicted)	FEV ₁/VC	AUC(CV _T) (%)
Healthy volunteers	H1	F	51	132	0.85	52
	H2	F	68	98	0.77	75
	H3	M	75	122	0.73	57
	H4	M	69	89	0.69	72
	H5	M	50	111	0.83	71
Patients	P1	M	81	43	0.33	99
	P2	M	84	30	0.25	100
	P3	F	71	22	0.21	100
	P4	F	73	51	0.43	100
	P5	F	52	28	0.30	100

FEV ₁, forced expiratory volume in one second (% predicted; predicted normal values according to Hedenstrom [26, 27]), obstruction was defined as FEV ₁ /VC < 0.7 for ages <65 years and <0.65 for ages ≥65 years according to the Swedish guidelines for COPD [28], AUC(CV _T c, area under the curve defined by the CV_T value (for details see ‘Methods’).