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EJNMMI Research

Table 3 BP ND for [ 11 C]prucalopride in rat brain regions versus cerebellum

From: Radiosynthesis and preclinical evaluation of [11C]prucalopride as a potential agonist PET ligand for the 5-HT4 receptor

Brain region

Baseline

Tariquidar pre-treatment

Striatum

0.00 ± 0.08

0.07 ± 0.09**

Hippocampus

−0.05 ± 0.05

0.07 ± 0.05*

Frontal cortex

0.04 ± 0.07

0.03 ± 0.04

Posterior cortex

0.00 ± 0.05

0.03 ± 0.04

  1. BPND for [11C]prucalopride in rat brain regions, at baseline and following pre-treatment with tariquidar (n = 4 for both conditions). Significant difference compared with baseline: *p < 0.05, **p < 0.01.
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