[11C]AF150(S), an agonist PET ligand for M1 muscarinic acetylcholine receptors

EJNMMI Research

Table 4 BP _ND of [ ¹¹ C]AF150(S) without and with co-injection of cold AF150(S)

Brain region	+1 nmol of cold AF150(S)		+5 nmol of cold AF150(S)		+15 nmol of cold AF150(S)
	Baseline	Co-injected	Baseline	Co-injected	Baseline	Co-injected
Left striatum	0.23 ± 0.02	0.21 ± 0.02	0.26 ± 0.06	0.25 ± 0.09	0.28 ± 0.08	0.31 ± 0.11
Right striatum	0.24 ± 0.01	0.23 ± 0.02	0.26 ± 0.06	0.26 ± 0.09	0.30 ± 0.07	0.32 ± 0.11
Hippocampus	0.20 ± 0.01	0.18 ± 0.03	0.23 ± 0.04	0.23 ± 0.07	0.24 ± 0.04	0.26 ± 0.08
Frontal cortical area	0.11 ± 0.04	0.08 ± 0.03	0.16 ± 0.06	0.14 ± 0.09	0.17 ± 0.09	0.18 ± 0.12
Posterior cortical area	0.08 ± 0.05	0.06 ± 0.04	0.16 ± 0.05	0.13 ± 0.07	0.14 ± 0.07	0.13 ± 0.09

Statistical analysis: significant difference between baseline and co-injected, p ≥ 0.12.