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Table 4 BP ND of [ 11 C]AF150(S) without and with co-injection of cold AF150(S)

From: [11C]AF150(S), an agonist PET ligand for M1 muscarinic acetylcholine receptors

Brain region +1 nmol of cold AF150(S) +5 nmol of cold AF150(S) +15 nmol of cold AF150(S)
  Baseline Co-injected Baseline Co-injected Baseline Co-injected
Left striatum 0.23 ± 0.02 0.21 ± 0.02 0.26 ± 0.06 0.25 ± 0.09 0.28 ± 0.08 0.31 ± 0.11
Right striatum 0.24 ± 0.01 0.23 ± 0.02 0.26 ± 0.06 0.26 ± 0.09 0.30 ± 0.07 0.32 ± 0.11
Hippocampus 0.20 ± 0.01 0.18 ± 0.03 0.23 ± 0.04 0.23 ± 0.07 0.24 ± 0.04 0.26 ± 0.08
Frontal cortical area 0.11 ± 0.04 0.08 ± 0.03 0.16 ± 0.06 0.14 ± 0.09 0.17 ± 0.09 0.18 ± 0.12
Posterior cortical area 0.08 ± 0.05 0.06 ± 0.04 0.16 ± 0.05 0.13 ± 0.07 0.14 ± 0.07 0.13 ± 0.09
  1. Statistical analysis: significant difference between baseline and co-injected, p ≥ 0.12.