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Table 1 Ex vivo distribution of [ 18 F]FDOPA in sham-operated and tumour-bearing mice (% ID/g)

From: Enzyme inhibition of dopamine metabolism alters 6-[18F]FDOPA uptake in orthotopic pancreatic adenocarcinoma

Organ Pretreatment
  Vehicle Carbidopa Ro-41-0960 Clorgyline Ro-41-0960 + clorgyline
  None a AADC a COMT a MAO-A a COMT + MAO-A a
  Sham Tumour Sham Tumour Sham Tumour Sham Tumour Sham Tumour
  n = 6 n = 5 n = 6 n = 6 n = 2 n = 5 n = 2 n = 5 n = 6 n = 5
Pancreasb 7.3 ± 1.9 4.4 ± 2.6 24.9 ± 4.4 18.9 ± 11.9 6.8 ± 2.2 8,9 ± 2,7 7.1 ± 2.3 9.0 ± 2.3 20.4 ± 5.6 5.9 ± 4.7
Muscle 0.8 ± 0.2 1.1 ± 0.5 2.0 ± 0.5 2.2 ± 1.3 1.2 ± 0.1 1.6 ± 0.5 1.0 ± 0.0 0.9 ± 0.1 0.9 ± 0.2 1.0 ± 0.3
Liver 7.4 ± 0.6 9.7 ± 1.5 4.2 ± 0.7 4.6 ± 0.9 7.5 ± 0.5 8.2 ± 2.7 8.8 ± 0.6 7.6 ± 1.5 7.7 ± 0.8 7.6 ± 1.4
Blood 1.3 ± 0.3 1.5 ± 0.3 3.1 ± 0.5 3.3 ± 0.8 1.8 ± 0.2 2.7 ± 0.5 1.4 ± 0.0 1.3 ± 0.1 2.1 ± 0.4 2.5 ± 1.3
Heart 1.6 ± 0.4 1.9 ± 0.3 4.2 ± 0.9 4.3 ± 1.1 2.3 ± 0.3 3.5 ± 0.9 1.7 ± 0.1 1.6 ± 0.2 3.4 ± 0.2 3.6 ± 0.9
Kidneys 6.7 ± 1.6 7.8 ± 1.4 22.8 ± 3.9 19.2 ± 6.4 9.0 ± 3.1 22.0 ± 17.5 8.8 ± 4.8 6.3 ± 0.4 28.2 ± 10.7 25.9 ± 5.7
Spleen 1.6 ± 0.4 1.7 ± 0.3 4.4 ± 0.9 4.9 ± 1.5 2.8 ± 0.3 2.9 ± 0.8 1.8 ± 0.0 1.7 ± 0.3 2.9 ± 0.6 2.8 ± 0.9
Small intestine 6.2 ± 1.2 5.8 ± 1.0 4.0 ± 0.9 4.3 ± 0.8 7.0 ± 0.3 5.1 ± 0.8 10.1 ± 1.2 10.0 ± 1.9 11.1 ± 2.2 11.6 ± 1.3
Large intestine 1.2 ± 0.4 1.3 ± 0.4 1.8 ± 0.2 2.3 ± 0.5 1.5 ± 0.1 1.7 ± 0.2 2.1 ± 0.4 1.9 ± 0.3 2.9 ± 0.4 3.6 ± 1.6
  1. Values are shown as mean ± standard deviation. aTarget enzyme; bpancreata of BxPC3 tumour-bearing animals were measured with tumours.