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EJNMMI Research

Table 1 Ex vivo distribution of [ 18 F]FDOPA in sham-operated and tumour-bearing mice (% ID/g)

From: Enzyme inhibition of dopamine metabolism alters 6-[18F]FDOPA uptake in orthotopic pancreatic adenocarcinoma

Organ

Pretreatment

 

Vehicle

Carbidopa

Ro-41-0960

Clorgyline

Ro-41-0960 + clorgyline

 

None a

AADC a

COMT a

MAO-A a

COMT + MAO-A a

 

Sham

Tumour

Sham

Tumour

Sham

Tumour

Sham

Tumour

Sham

Tumour

 

n = 6

n = 5

n = 6

n = 6

n = 2

n = 5

n = 2

n = 5

n = 6

n = 5

Pancreasb

7.3 ± 1.9

4.4 ± 2.6

24.9 ± 4.4

18.9 ± 11.9

6.8 ± 2.2

8,9 ± 2,7

7.1 ± 2.3

9.0 ± 2.3

20.4 ± 5.6

5.9 ± 4.7

Muscle

0.8 ± 0.2

1.1 ± 0.5

2.0 ± 0.5

2.2 ± 1.3

1.2 ± 0.1

1.6 ± 0.5

1.0 ± 0.0

0.9 ± 0.1

0.9 ± 0.2

1.0 ± 0.3

Liver

7.4 ± 0.6

9.7 ± 1.5

4.2 ± 0.7

4.6 ± 0.9

7.5 ± 0.5

8.2 ± 2.7

8.8 ± 0.6

7.6 ± 1.5

7.7 ± 0.8

7.6 ± 1.4

Blood

1.3 ± 0.3

1.5 ± 0.3

3.1 ± 0.5

3.3 ± 0.8

1.8 ± 0.2

2.7 ± 0.5

1.4 ± 0.0

1.3 ± 0.1

2.1 ± 0.4

2.5 ± 1.3

Heart

1.6 ± 0.4

1.9 ± 0.3

4.2 ± 0.9

4.3 ± 1.1

2.3 ± 0.3

3.5 ± 0.9

1.7 ± 0.1

1.6 ± 0.2

3.4 ± 0.2

3.6 ± 0.9

Kidneys

6.7 ± 1.6

7.8 ± 1.4

22.8 ± 3.9

19.2 ± 6.4

9.0 ± 3.1

22.0 ± 17.5

8.8 ± 4.8

6.3 ± 0.4

28.2 ± 10.7

25.9 ± 5.7

Spleen

1.6 ± 0.4

1.7 ± 0.3

4.4 ± 0.9

4.9 ± 1.5

2.8 ± 0.3

2.9 ± 0.8

1.8 ± 0.0

1.7 ± 0.3

2.9 ± 0.6

2.8 ± 0.9

Small intestine

6.2 ± 1.2

5.8 ± 1.0

4.0 ± 0.9

4.3 ± 0.8

7.0 ± 0.3

5.1 ± 0.8

10.1 ± 1.2

10.0 ± 1.9

11.1 ± 2.2

11.6 ± 1.3

Large intestine

1.2 ± 0.4

1.3 ± 0.4

1.8 ± 0.2

2.3 ± 0.5

1.5 ± 0.1

1.7 ± 0.2

2.1 ± 0.4

1.9 ± 0.3

2.9 ± 0.4

3.6 ± 1.6

  1. Values are shown as mean ± standard deviation. aTarget enzyme; bpancreata of BxPC3 tumour-bearing animals were measured with tumours.
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